Diabetic nephropathy - complications and treatment.
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TLDR
This review will examine the current concepts of diabetic nephropathy management in the context of some of the basic science and pathophysiology aspects relevant to the approaches taken in novel, investigative treatment strategies.Abstract:
Diabetic nephropathy is a significant cause of chronic kidney disease and end-stage renal failure globally Much research has been conducted in both basic science and clinical therapeutics, which has enhanced understanding of the pathophysiology of diabetic nephropathy and expanded the potential therapies available This review will examine the current concepts of diabetic nephropathy management in the context of some of the basic science and pathophysiology aspects relevant to the approaches taken in novel, investigative treatment strategiesread more
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Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment.
TL;DR: In this article, the role of inflammation and oxidative stress in the pathogenesis of nonproteinuric diabetic nephropathy (NP-DN) is discussed. But, there are problems in diagnosis and treatment of NP-DN, which does not follow the classic pattern of DN, and additional therapy is needed to prevent or ameliorate the condition.
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From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research
Radia Marium Modhumi Khan,Zoey Jia Yu Chua,Jia Chi Tan,Yingying Yang,Yingying Yang,Zehuan Liao,Yan Zhao +6 more
TL;DR: To prevent pre-diabetes from developing into type 2 diabetes mellitus (T2DM), lifestyle intervention has been found to be very promising and various aspects of diabetes, including the aforementioned topics, have been reviewed.
Journal ArticleDOI
Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets
TL;DR: The purpose of this review is to describe the current understanding of how the hemodynamic, metabolic, inflammatory, and alternative pathways are all entangled in pathogenesis of DKD and detail the various therapeutic targets that may one day play a role in quelling this epidemic.
Journal ArticleDOI
Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy
Cristina Grange,Stefania Tritta,Marta Tapparo,Massimo Cedrino,Ciro Tetta,Giovanni Camussi,Maria Felice Brizzi +6 more
TL;DR: Stem cell-derived EVs inhibit fibrosis and prevent its progression in a model of diabetes-induced chronic kidney injury, as induced by streptozotocin.
References
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Diabetes Control,David M. Nathan,Saul M. Genuth,John M. Lachin,Patricia A. Cleary,O Crofford,Matthew M. Davis,Larry Rand,Carolyn Siebert +8 more
TL;DR: Intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy, nephropathy, and neuropathy in patients with IDDM.
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TL;DR: In this article, a randomized controlled trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly people was presented. But the authors did not discuss the effect of the combination therapy in patients living with systolic hypertension.
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TL;DR: 2007 Guidelines for the Management of Arterial Hypertension : The Task Force for the management of Arterspertension of the European Society ofhypertension (ESH) and of theEuropean Society of Cardiology (ESC).
Journal ArticleDOI
Standards of medical care in diabetes.
TL;DR: I would like to take issue with the use of the phrase “standards of medical care in diabetes,” which is used to describe diabetes care standards, in the recently updated and circulatedADA 2006 Clinical Practice Recommendations.
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2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)
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TL;DR: Although this guideline provides evidence-based recommendations for the management of high BP and should meet the clinical needs of most patients, these recommendations are not a substitute for clinical judgment, and decisions about care must carefully consider and incorporate the clinical characteristics and circumstances of each individual patient.