Diagnosis and Management of Clinical Chorioamnionitis
TLDR
Clinical research into better methods for diagnosing, treating, and preventing chorioamnionitis is likely to have a substantial impact on short and long-term outcomes in the neonate.About:
This article is published in Clinics in Perinatology.The article was published on 2010-06-01 and is currently open access. It has received 673 citations till now. The article focuses on the topics: Chorioamnionitis & Neonatal sepsis.read more
Citations
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ACOG practice bulletin: Clinical management guidelines for obstetrician-gynecologists
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Early-Onset Neonatal Sepsis
TL;DR: Early-onset sepsis remains a common and serious problem for neonates, especially preterm infants, and efforts toward maternal intrapartum antimicrobial prophylaxis have significantly reduced the rates of GBS disease but have been associated with increased rates of Gram-negative infections.
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Management of neonates with suspected or proven early-onset bacterial sepsis.
Richard A. Polin,Newborn +1 more
TL;DR: The purpose of this clinical report is to provide a practical and, when possible, evidence-based approach to the management of infants with suspected or proven early-onset sepsis.
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Evaluation and Management of Women and Newborns with a Maternal Diagnosis of Chorioamnionitis: Summary of a Workshop
Rosemary D. Higgins,George R. Saade,Richard A. Polin,William A. Grobman,Irina A. Buhimschi,Kristi L. Watterberg,Robert M. Silver,Tonse N.K. Raju +7 more
TL;DR: An expert panel was invited to a workshop to address numerous knowledge gaps and to provide evidence-based guidelines for the diagnosis and management of pregnant women with what had been commonly called chorioamnionitis and the neonates born to these women.
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Developmental dynamics of the preterm infant gut microbiota and antibiotic resistome.
Molly K. Gibson,Bin Wang,Sara Ahmadi,Carey-Ann D. Burnham,Phillip I. Tarr,Barbara B. Warner,Gautam Dantas +6 more
TL;DR: Analysis of 401 stools from 84 longitudinally sampled preterm infants demonstrates that meropenem, cefotaxime and ticarcillin–clavulanate are associated with significantly reduced species richness, but analysis of deep shotgun sequencing of all stools finds that multidrug-resistant members of the genera Escherichia, Klebsiella and Enterobacter dominate the preterm infant gut microbiota.
References
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Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC.
TL;DR: Although universal screening for GBS colonization is anticipated to result in further reductions in the burden of GBS disease, the need to monitor for potential adverse consequences of intrapartum antibiotic use, such as emergence of bacterial antimicrobial resistance or increased incidence or severity of non-GBS neonatal pathogens, continues.
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The fetal inflammatory response syndrome.
TL;DR: The fetal systemic inflammatory response as a mechanism of disease is reviewed and potential interventions to control an exaggerated inflammatory response in utero are also described.
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Antecedents of cerebral palsy. Multivariate analysis of risk.
TL;DR: Prenatal and perinatal factors predicting cerebral palsy were examined using multivariate analysis to investigate which factors were most important and the proportion of cases for which they accounted, and maternal mental retardation, birth weight below 2001 g, and fetal malformation were among the leading predictors.
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Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial
TL;DR: Erythromycin for women with pPRom is associated with a range of health benefits for the neonate, and thus a probable reduction in childhood disability, but co-amoxiclav cannot be routinely recommended for pPROM because of its association with neonatal necrotising enterocolitis.
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Mycoplasmas and Ureaplasmas as Neonatal Pathogens
TL;DR: This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to Mycoplasma and urea plasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.