Drug-induced impairment of renal function
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TLDR
This article will review those drugs that are associated with impaired renal function and provide an overview of nephrotoxic drugs that a treating physician is most likely to encounter by focusing on pharmaceutical agents that are currently in clinical practice.Abstract:
Pharmaceutical agents provide diagnostic and therapeutic utility that are central to patient care. However, all agents also carry adverse drug effect profiles. While most of these are clinically insignificant, some drugs may cause unacceptable toxicity that impacts negatively on patient morbidity and mortality. Recognizing adverse effects is important for administering appropriate drug doses, instituting preventive strategies, and withdrawing the offending agent due to toxicity. In the present article, we will review those drugs that are associated with impaired renal function. By focusing on pharmaceutical agents that are currently in clinical practice, we will provide an overview of nephrotoxic drugs that a treating physician is most likely to encounter. In doing so, we will summarize risk factors for nephrotoxicity, describe clinical manifestations, and address preventive and treatment strategies.read more
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Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis.
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Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children
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TL;DR: In this paper, the effects of kidney function on drug exposure and response and fine-tune dosing in pediatric patients, especially in those with impaired kidney function is presented. But the authors do not consider the effect of kidney injury and chronic diseases.
References
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