Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
Yao Fu,Weiyuan John Kao +1 more
TLDR
An overview of structure-function relationships of selected non-degradable and degradable polymers as drug delivery matrices is provided to help elucidate the solute transport mechanisms.Abstract:
Importance of the field: The advancement in material design and engineering has led to the rapid development of new materials with increasing complexity and functions. Both non-degradable and degradable polymers have found wide applications in the controlled delivery field. Studies on drug release kinetics provide important information into the function of material systems. To elucidate the detailed transport mechanism and the structure-function relationship of a material system, it is critical to bridge the gap between the macroscopic data and the transport behavior at the molecular level.Areas covered in this review: The structure and function information of selected non-degradable and degradable polymers have been collected and summarized from literature published after the 1990s. The release kinetics of selected drug compounds from various material systems is discussed in case studies. Recent progress in the mathematical models based on different transport mechanisms is highlighted.What the reader wil...read more
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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
Journal ArticleDOI
Drug delivery systems and materials for wound healing applications.
Saghi Saghazadeh,Chiara Rinoldi,Maik Schot,Sara Saheb Kashaf,Fatemeh Sharifi,Elmira Jalilian,Kristo Nuutila,Giorgio Giatsidis,Pooria Mostafalu,Hossein Derakhshandeh,Kan Yue,Wojciech Swieszkowski,Adnan Memic,Ali Tamayol,Ali Khademhosseini +14 more
TL;DR: The pathophysiology of chronic wounds is discussed and then the materials used for engineering drug delivery systems are discussed, and the architecture of the delivery platform and its ability to modulate drug delivery are discussed.
Journal ArticleDOI
Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology
Aleksandra Zielińska,Filipa Carreiró,Ana Oliveira,Andreia Neves,Bárbara Pires,D. Nagasamy Venkatesh,Alessandra Durazzo,Massimo Lucarini,Piotr Eder,Amélia M. Silva,Antonello Santini,Eliana B. Souto +11 more
TL;DR: The most commonly used methods for the production and characterization of polymeric NPs are discussed, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms are discussed.
Journal ArticleDOI
Effect of process and formulation variables on the preparation of parenteral paclitaxel-loaded biodegradable polymeric nanoparticles: A co-surfactant study
TL;DR: It was concluded that the particle size of the nanoparticles could be reduced further and the paclitaxel release kinetics could easily be adjusted by taking advantage by the inclusion of a co-surfactant.
Journal ArticleDOI
Temperature Treatment of Highly Porous Zirconium-Containing Metal-Organic Frameworks Extends Drug Delivery Release
Michelle H. Teplensky,Marcus Fantham,Peng Li,Timothy C. Wang,Joshua P. Mehta,Laurence J. Young,Peyman Z. Moghadam,Joseph T. Hupp,Omar K. Farha,Omar K. Farha,Clemens F. Kaminski,David Fairen-Jimenez +11 more
TL;DR: It is found that addition of a model drug compound into the MOF and the subsequent temperature treatment process does not affect the rate of MOF uptake by the cell, and endocytosis analysis revealed that MOFs are internalized by active transport and that inhibiting the caveolae-mediated pathway significantly reduced cellular uptake of MOFs.
References
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Xiao Huang,Christopher S. Brazel +1 more
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Chien-Chi Lin,Andrew T. Metters +1 more
TL;DR: The objective of this article is to review the fundamentals and recent advances in hydrogel network design as well as mathematical modeling approaches related to controlled molecule release from hydrogels.