Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States.
Bruce W. Bode,Valerie Garrett,Jordan Messler,Raymie McFarland,Jennifer Crowe,Robby Booth,David C. Klonoff +6 more
TLDR
This retrospective observational study of laboratory-confirmed COVID-19 adults evaluated glycemic and clinical outcomes in patients with and without diabetes and/or acutely uncontrolled hyperglycemia hospitalized March 1 to April 6, 2020, finding that patients with diabetes and or uncontrolled hyper glycemia had a longer LOS and markedly higher mortality than patients without diabetes.Abstract:
Introduction:Diabetes has emerged as an important risk factor for severe illness and death from COVID-19. There is a paucity of information on glycemic control among hospitalized COVID-19 patients ...read more
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Risk factors for severe and critically ill COVID-19 patients: A review.
Ya-dong Gao,Mei Ding,Mei Ding,Xiang Dong,Jin-jin Zhang,Ahmet Kursat Azkur,Dilek Azkur,Hui Gan,Yuan-Li Sun,Wei Fu,Wei Li,Hui-ling Liang,Yiyuan Cao,Qi Yan,Can Cao,Hong-yu Gao,Marie-Charlotte Brüggen,Willem van de Veen,Milena Sokolowska,Mübeccel Akdis,Cezmi A. Akdis +20 more
TL;DR: In this review, the scientific evidence on the risk factors of severity of COVID‐19 are highlighted and socioeconomic status, diet, lifestyle, geographical differences, ethnicity, exposed viral load, day of initiation of treatment, and quality of health care have been reported to influence individual outcomes.
Journal ArticleDOI
Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study.
Emma Barron,Chirag Bakhai,Partha Kar,Andy Weaver,Dominique Bradley,Hassan Ismail,Peter Knighton,Naomi Holman,Kamlesh Khunti,Naveed Sattar,Nicholas J. Wareham,Bob Young,Jonathan Valabhji,Jonathan Valabhji,Jonathan Valabhji +14 more
TL;DR: The results of this nationwide analysis in England show that type 1 and type 2 diabetes were both independently associated with a significant death with COVID-19, and the effects were attenuated to ORs of 2·86 (2·58–3·18) for type 1 diabetes and 1·80 (1·75–1·86) fortype 2 diabetes when also adjusted for previous hospital admissions with coronary heart disease, cerebrovascular disease, or heart failure.
Journal ArticleDOI
Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study.
Naomi Holman,Naomi Holman,Peter Knighton,Partha Kar,Jackie O'Keefe,Matt Curley,Andy Weaver,Emma Barron,Chirag Bakhai,Kamlesh Khunti,Nicholas J. Wareham,Naveed Sattar,Bob Young,Jonathan Valabhji,Jonathan Valabhji,Jonathan Valabhji +15 more
TL;DR: Male sex, older age, renal impairment, non-white ethnicity, socioeconomic deprivation, and previous stroke and heart failure were associated with increased COVID-19-related mortality in both type 1 and type 2 diabetes.
Journal ArticleDOI
COVID-19 in people with diabetes: understanding the reasons for worse outcomes.
Matteo Apicella,Maria Cristina Campopiano,Michele Mantuano,Laura Mazoni,Alberto Coppelli,Stefano Del Prato +5 more
TL;DR: The reason for worse prognosis in people with diabetes is likely to be multifactorial, thus reflecting the syndromic nature of diabetes, and age, sex, ethnicity, comorbidities such as hypertension and cardiovascular disease, obesity, and a pro-inflammatory and pro-coagulative state all probably contribute to the risk of worse outcomes.
References
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Journal ArticleDOI
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
Giacomo Grasselli,Giacomo Grasselli,Alberto Zangrillo,Alberto Zanella,Alberto Zanella,Massimo Antonelli,Massimo Antonelli,Luca Cabrini,Antonio Castelli,Danilo Cereda,Antonio Coluccello,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Nicola Latronico,Luca Lorini,Stefano Merler,Giuseppe Natalini,Alessandra Piatti,Marco Ranieri,Anna Mara Scandroglio,Enrico Storti,Maurizio Cecconi,Antonio Pesenti,Antonio Pesenti +24 more
TL;DR: Patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy were characterized, including data on clinical management, respiratory failure, and patient mortality.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes,Laura Evans,Waleed Alhazzani,Mitchell M. Levy,Massimo Antonelli,Ricard Ferrer,Anand Kumar,Jonathan E. Sevransky,Charles L. Sprung,Mark E. Nunnally,Bram Rochwerg,Gordon D. Rubenfeld,Derek C. Angus,Djillali Annane,Richard Beale,Geoffrey J. Bellinghan,Gordon R. Bernard,Jean Daniel Chiche,Craig M. Coopersmith,Daniel De Backer,Craig French,Seitaro Fujishima,Herwig Gerlach,Jorge Hidalgo,Steven M. Hollenberg,Alan E. Jones,Dilip R. Karnad,Ruth M. Kleinpell,Younsuck Koh,Thiago Lisboa,Flávia Ribeiro Machado,John J. Marini,John C. Marshall,John E. Mazuski,Lauralyn McIntyre,Anthony S. McLean,Sangeeta Mehta,Rui Moreno,John Myburgh,Paolo Navalesi,Osamu Nishida,Tiffany M. Osborn,Anders Perner,Colleen M. Plunkett,Marco Ranieri,Christa A. Schorr,Maureen A. Seckel,Christopher W. Seymour,Lisa Shieh,Khalid A. Shukri,Steven Q. Simpson,Mervyn Singer,B. Taylor Thompson,Sean R. Townsend,Thomas Van der Poll,Jean Louis Vincent,W. Joost Wiersinga,Janice L. Zimmerman,R. Phillip Dellinger +58 more
TL;DR: Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Journal ArticleDOI
Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 - COVID-NET, 14 States, March 1-30, 2020.
Shikha Garg,Shikha Garg,Lindsay Kim,Michael Whitaker,Alissa O’Halloran,Charisse N Cummings,Rachel Holstein,Mila M. Prill,Shua J Chai,Pam Daily Kirley,Nisha B Alden,Breanna Kawasaki,Kimberly Yousey-Hindes,Linda M. Niccolai,Evan J. Anderson,Evan J. Anderson,Kyle P Openo,Andrew Weigel,Maya Monroe,Patricia Ryan,Justin Henderson,Sue Kim,Kathy Como-Sabetti,Ruth Lynfield,Daniel M. Sosin,Salina Torres,Alison Muse,Nancy M. Bennett,Laurie M Billing,Melissa Sutton,Nicole West,William Schaffner,H. Keipp Talbot,Clarissa Aquino,Andrea George,Alicia P Budd,Lynnette Brammer,Gayle E Langley,Aron J. Hall,Alicia M. Fry +39 more
TL;DR: It is suggested that older adults have elevated rates of COVID-19-associated hospitalization and the majority of persons hospitalized with CO VID-19 have underlying medical conditions, which underscore the importance of preventive measures to protect older adults and persons with underlyingmedical conditions, as well as the general public.
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