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Hepatitis B Virus Infection in Iran: A Systematic Review

TLDR
About 1.5 million people in Iran are living with HBV infection and it is assumed that 15% to 40% of them are at risk of developing cirrhosis and/or hepatocellular carcinoma (HCC) without intervention.
Abstract
Results: Fourteen studies met the inclusion criteria. They were from 7 (out of 30) provinces in which about 40 percent of the country population live. These provinces (HBsAg positive prevalence) were Golestan (6.3%), Tehran (2.2%), East Azarbaijan (1.3%), Hamedan (2.3%), Isfahan (1.3%), Kermanshah (1.3%) and Hormozgan (2.4%). The HBV infection prevalence in Iran is estimated to be 2.14 percent (95%CI: 1.92-2.35), in men and women 2.55 percent (95%CI: 2.252.85) and 2.03 percent (95%CI: 1.6-2.46 percent) respectively. Conclusions: About 1.5 million people in Iran are living with HBV infection (mild to moderate prevalence according to WHO classification) and it is assumed that 15% to 40% of them are at risk of developing cirrhosis and/or hepatocellular carcinoma (HCC) without intervention. The prevalence of HBV infection has been reported higher in more recent studies compared to the study in 2000-2001.

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Citations
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Book ChapterDOI

Global Epidemiology of Hepatitis B Virus Infection

TL;DR: The great impact of routine infant and childhood hepatitis B immunization programs, which have caused a dramatic reduction of HBsAg carriage in immunized cohorts of children, and have led to significant decreases in HBV transmission and the occurrence of related cirrhosis and liver cancer in various populations are noted.
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Hepatitis B in Ghana: a systematic review & meta-analysis of prevalence studies (1995-2015).

TL;DR: Hepatitis B infection is clearly an important public health problem in Ghana and the burden of the disease as dictated by a high prevalence rate calls for urgent public health interventions and strategic policy directions to controlling the disease.
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Hepatitis B virus infection in dentistry: a forgotten topic

TL;DR: The HBV incidence in dental society, the points of view of dentists and their patients regarding transmission of the virus during dental procedures, the occurrence of HBV outbreaks in dental clinics and the importance of methods of preventing HBV infection in dentistry are reviewed.
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High prevalence of occult hepatitis B virus infection in children born to HBsAg-positive mothers despite prophylaxis with hepatitis B vaccination and HBIG.

TL;DR: HBV occult infection seems to be relatively frequent in immunized children born to HBsAg-positive mothers, and the importance of considering occult HBV infection in hypo-endemic areas is emphasized.
References
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Journal ArticleDOI

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TL;DR: Current data suggest that antiviral therapy can decrease the risk of liver decompensation and liver-related death and reduce therisk of HCC in selected individuals with active liver disease and severe fibrosis.
Journal Article

The changing epidemiology of viral hepatitis B in Iran.

TL;DR: Intensifying HB vaccination of high risk groups, surveillance of hepatitis B infected subjects, and control on health state of refugees will further decrease the frequency of the disease in Iranian population.
Journal Article

Epidemiology of hepatitis B, hepatitis C, and human immunodeficiency virus infecions in patients with beta-thalassemia in Iran: a multicenter study.

TL;DR: The prevalence of HCV infection is much higher among Iranian beta-thalassemic patients as compared with HBV and HIV infections, and routine screening of donated blood for HCV is highly recommended.
Journal ArticleDOI

Epidemiology of hepatitis b in the islamic republic of iran

TL;DR: Older males living in a village with low socioeconomic status, poor sanitation and intrafamily contact are the most important contributors to the rise of hepatitis B infection in the country.
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