HIV-associated multicentric Castleman's disease.
TLDR
The case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia is presented.Abstract:
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often based only on published case reports. Systemic treatments for MCD have included chemotherapy, anti-herpes virus, highly active antiretroviral therapy and, more recently, monoclonal antibodies against both IL6 and CD20.read more
Citations
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Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV–MCD) and the KSHV Inflammatory Cytokine Syndrome
TL;DR: The clinical presentation of KSHV–MCD is dominated by systemic inflammatory symptoms including fevers, cachexia, and laboratory abnormalities including cytopenias, hypoalbuminemia, hyponatremia, and elevated C-reactive protein.
Journal ArticleDOI
Human herpesvirus-8: Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma
TL;DR: Identification of pathogenetic mechanisms has led to exploration of targeted treatment approaches for all 3 of these disorders with success in Kaposi sarcoma and multicentric Castleman disease; primary effusion lymphoma remains a clinical challenge.
Journal ArticleDOI
Plasma HHV8 DNA predicts relapse in individuals with HIV-associated multicentric Castleman disease
Justin Stebbing,Caroline Adams,Adam Sanitt,Salvinia Mletzko,Mark Nelson,Brian Gazzard,Tom Newsom-Davis,Mark Bower +7 more
TL;DR: Rising levels of human herpesvirus-8 DNA predicted an attack in individuals with a histologic diagnosis of HIV-MCD, and maintenance therapy with rituximab should be considered in these individuals.
Journal ArticleDOI
Castleman's disease—a two compartment model of HHV8 infection
Klaus-Martin Schulte,Nadia Talat +1 more
TL;DR: Lymphovascular endothelium and naive B cells are infectious reservoir-opening options for antiangiogenic and anti-CD19 strategies to enhance outcomes in patients with systemic disease.
Journal ArticleDOI
Haematological manifestations of human immune deficiency virus infection
TL;DR: The epidemiology and aetiology of select non‐oncological haematological disorders commonly seen in people living with HIV‐acquired immune deficiency syndrome are reviewed.
References
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Journal ArticleDOI
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
Jean Soulier,Laurence Grollet,Eric Oksenhendler,Patrice Cacoub,Dominique Cazals-Hatem,Paul Babinet,Marie-Françoise D'Agay,Jean-Pierre Clauvel,Marline Raphael,Laurent Degos,François Sigaux +10 more
TL;DR: Data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients, which is a close association with Kaposi's sarcoma.
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Localized mediastinal lymph‐node hyperplasia resembling thymoma
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Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease
Norihiro Nishimoto,Yuzuru Kanakura,Katsuyuki Aozasa,Takeshi Johkoh,Minoru Nakamura,Shuji Nakano,Nobuaki Nakano,Yasuo Ikeda,Takeshi Sasaki,Kiyoshi Nishioka,Masamichi Hara,Hirokuni Taguchi,Yukihiko Kimura,Yoshiro Kato,Hideki Asaoku,Shunichi Kumagai,F Kodama,H. Nakahara,Keisuke Hagihara,Kazuyuki Yoshizaki,Tadamitsu Kishimoto +20 more
TL;DR: Hemoglobin, albumin, and total cholesterol levels, high-density lipoprotein cholesterol values, and body mass index all increased significantly, and fatigue diminished, in patients with MCD.
Journal ArticleDOI
The Clinical Behavior of Localized and Multicentric Castleman Disease
TL;DR: The clinical features at presentation, clinicopathologic correlations, treatments, and outcomes of the 15 patients diagnosed with localized or multicentric Castleman disease are described.
Journal Article
A systemic lymphoproliferative disorder with morphologic features of Castleman's disease
TL;DR: In this paper, a review of 50 cases in the literature revealed similar clinical and laboratory features, and the main features of this process seem to best fit a hyperplastic-dysplastic lymphoid disorder in a setting of immunoregulatory deficit.