Hydrogels in drug delivery: progress and challenges
Todd Hoare,Daniel S. Kohane +1 more
TLDR
Recent progress in overcoming challenges with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs fromhydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches is discussed.About:
This article is published in Polymer.The article was published on 2008-04-15 and is currently open access. It has received 3140 citations till now. The article focuses on the topics: Self-healing hydrogels & Drug delivery.read more
Citations
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Designing hydrogels for controlled drug delivery.
Jianyu Li,David J. Mooney +1 more
TL;DR: This Review discusses how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation, and collects experimental release data from the literature and presents quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
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Chitosan-based hydrogels for controlled, localized drug delivery
TL;DR: The newest developments in chitosan hydrogel preparation are investigated and the design parameters in the development of physically and chemically cross-linked hydrogels are defined.
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Biomedical applications of hydrogels: A review of patents and commercial products
TL;DR: From Wichterle’s pioneering work to the most recent hydrogel-based inventions and products on the market, it provides the reader with a detailed introduction to the topic and perspective on further potential developments.
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
References
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Novel crosslinking methods to design hydrogels
Wim E. Hennink,C.F. van Nostrum +1 more
TL;DR: In this overview, different chemical and physical crosslinking methods used for the design of biodegradable hydrogels are summarized and discussed.
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In situ-forming hydrogels--review of temperature-sensitive systems.
TL;DR: This manuscript focuses on aqueous polymeric solutions that form implants in situ in response to temperature change, generally from ambient to body temperature, and mainly reviews the characterization and use of polysaccharides, N-isopropylacrylamide copolymers, poly(ethylene oxide) (poloxamer) and itsCopolymers.
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Poly(lactide) Stereocomplexes: Formation, Structure, Properties, Degradation, and Applications
TL;DR: The methods for tracing PLA stereocomplexation, the methods for inducing PLA stereocompelxation, and the parameters affecting PLA stereoconplexation are reviewed to open a new way for the preparation of biomaterials such as hydrogels and particles for drug delivery systems.
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A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.
TL;DR: The results clearly suggested that the genipin-cross-linked NOCC/alginate hydrogel could be a suitable polymeric carrier for site-specific protein drug delivery in the intestine.