Important Flavonoids and Their Role as a Therapeutic Agent.
Asad Ullah,S M Munir,Syed Lal Badshah,Noreen Khan,Lubna Ghani,Benjamin Gabriel Poulson,Abdul-Hamid M. Emwas,Mariusz Jaremko +7 more
TLDR
This work has made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.Abstract:
Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.read more
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Antiviral activities of flavonoids.
Syed Lal Badshah,Shah Faisal,Akhtar Muhammad,Benjamin Gabriel Poulson,Abdul-Hamid M. Emwas,Mariusz Jaremko +5 more
TL;DR: In this paper, the authors reviewed many flavonoids that showed antiviral activities in different testing environments such as in vitro, in vivo (mice model) and in silico.
Journal ArticleDOI
Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial
Francesco Di Pierro,Somia Iqtadar,Amjad Khan,Sami Ullah Mumtaz,Mohsin Masud Chaudhry,Alexander Bertuccioli,Giuseppe Derosa,Pamela Maffioli,Stefano Togni,Antonella Riva,Pietro Allegrini,Saeed Khan +11 more
TL;DR: In this paper, a 2-week, randomized, open-label, and controlled clinical study was conducted to evaluate the effect of quercetin phytosome R (QP) on mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in COVID-19 patients.
Journal ArticleDOI
Flavonoids as Potential Anti-Inflammatory Molecules: A Review
TL;DR: The anti-inflammatory properties of quercetin, genistein, apigenin, kaempferol, and epigallocatechin 3-gallate are discussed in this article .
Journal ArticleDOI
The role of plant‐derived natural antioxidants in reduction of oxidative stress
TL;DR: The role of natural therapeutic antioxidant effects to reduce oxidative stress in the diseases is explored and a wide range of biological impacts such as anti‐inflammatory, anti-aging, anti‐atherosclerosis, and anti‐cancer properties are demonstrated.
Journal ArticleDOI
Health Benefits of Quercetin in Age-Related Diseases
Deepika,Pawan Kumar Maurya +1 more
TL;DR: A detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out and it is proved that quercETin plays a crucial role in the prevention of age-related disorders.
References
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Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
TL;DR: It is suggested that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases.
Journal ArticleDOI
Chemistry and Biological Activities of Flavonoids: An Overview
Shashank Kumar,Abhay K. Pandey +1 more
TL;DR: The structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production are highlighted.
Journal ArticleDOI
Flavonoids: an overview
TL;DR: Current trends of research and development activities on flavonoid relate to isolation, identification, characterisation and functions of flavonoids and finally their applications on health benefits and future research directions are discussed.
Journal ArticleDOI
Flavonoids: a review of probable mechanisms of action and potential applications
Robert J. Nijveldt,Els Van Nood,Danny E. C. van Hoorn,Petra G. Boelens,Klaske van Norren,Paul A. M. van Leeuwen +5 more
TL;DR: The aim of this review, a summary of the putative biological actions of flavonoids, was to obtain a further understanding of the reported beneficial health effects of these substances.
Journal ArticleDOI
Flavonoids: antioxidants or signalling molecules?
TL;DR: A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration.
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