Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
TLDR
Most of the papers surveyed did not report using randomisation or blinding to reduce bias in animal selection and outcome assessment, consistent with reviews of many research areas, including clinical studies, published in recent years.Abstract:
animals used (i.e., species/strain, sex, and age/weight). Most of the papers surveyed did not report using randomisation (87%) or blinding (86%) to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods fully described them and presented the results with a measure of precision or variability [5]. These findings are a cause for concern and are consistent with reviews of many research areas, including clinical studies, published in recent years [2–22].read more
Citations
More filters
Journal ArticleDOI
Power failure: why small sample size undermines the reliability of neuroscience
Katherine S. Button,John P. A. Ioannidis,Claire Mokrysz,Brian A. Nosek,Jonathan Flint,Emma S J Robinson,Marcus R. Munafò +6 more
TL;DR: It is shown that the average statistical power of studies in the neurosciences is very low, and the consequences include overestimates of effect size and low reproducibility of results.
Journal ArticleDOI
Animal research: reporting in vivo experiments: the ARRIVE guidelines
TL;DR: An accurate summary of the background, research objectives, including details of the species or strain of animal used, key methods, principal findings and conclusions of the study is provided.
Journal ArticleDOI
Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines:
TL;DR: The following guidelines are excerpted (as permitted under the Creative Commons Attribution License (CCAL), with the knowledge and approval of PLoS Biology and the authors) from Kilkenny et al.
Journal ArticleDOI
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Nathalie Percie du Sert,Viki Hurst,Amrita Ahluwalia,Sabina Alam,Marc T. Avey,Monya Baker,William J Browne,Alejandra Clark,Innes C. Cuthill,Ulrich Dirnagl,Michael Emerson,Paul Garner,Stephen T. Holgate,David W. Howells,Natasha A. Karp,Stanley E. Lazic,Katie Lidster,Catriona J. MacCallum,Malcolm R. Macleod,Esther J. Pearl,Ole H. Petersen,Frances Rawle,Penny S. Reynolds,Kieron Rooney,Emily S. Sena,Shai D. Silberberg,Thomas Steckler,Hanno Würbel +27 more
TL;DR: The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) have been updated and information reorganised to facilitate their use in practice to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.
Journal ArticleDOI
SYRCLE’s risk of bias tool for animal studies
Carlijn R. Hooijmans,Maroeska M. Rovers,Rob B. M. de Vries,Marlies Leenaars,Merel Ritskes-Hoitinga,Miranda W. Langendam +5 more
TL;DR: Widespread adoption and implementation of this tool will facilitate and improve critical appraisal of evidence from animal studies and enhance the efficiency of translatingAnimal research into clinical practice and increase awareness of the necessity of improving the methodological quality of animal studies.
References
More filters
Journal ArticleDOI
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
TL;DR: The Consort 2010 Statement as discussed by the authors has been used worldwide to improve the reporting of randomised controlled trials and has been updated by Schulz et al. in 2010, based on new methodological evidence and accumulating experience.
Journal ArticleDOI
CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials
TL;DR: The 2010 version of the CONSORT Statement is described, which updates the previous reporting guideline based on new methodological evidence and accumulated experience.
Journal ArticleDOI
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
TL;DR: The revised CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results.
Journal ArticleDOI
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.
Alvis Brazma,Pascal Hingamp,John Quackenbush,Gavin Sherlock,Paul T. Spellman,Chris Stoeckert,John Aach,Wilhelm Ansorge,Catherine A. Ball,Helen C. Causton,Terry Gaasterland,Patrick Glenisson,Frank C. P. Holstege,Irene F. Kim,Victor Markowitz,John C. Matese,Helen Parkinson,Alan J. Robinson,Ugis Sarkans,Steffen Schulze-Kremer,Jason E. Stewart,Ronald C. Taylor,Jaak Vilo,Martin Vingron +23 more
TL;DR: The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.
Journal ArticleDOI
Animal research: reporting in vivo experiments: the ARRIVE guidelines
TL;DR: An accurate summary of the background, research objectives, including details of the species or strain of animal used, key methods, principal findings and conclusions of the study is provided.
Related Papers (5)
Drug development: Raise standards for preclinical cancer research
C. Glenn Begley,Lee M. Ellis +1 more