Journal ArticleDOI
Interleukin-1. A new mediator in dermatology.
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This article is published in International Journal of Dermatology.The article was published on 1987-01-01. It has received 496 citations till now. The article focuses on the topics: Interleukin & Epidermis (botany).read more
Citations
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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Jochen Schmitz,Alexander Owyang,Elizabeth R. Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad M. Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein +12 more
TL;DR: A member of theIL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T( H)2 cells is reported.
Journal ArticleDOI
Biology of interleukin 1.
TL;DR: IL 1 is a highly inflammatory molecule and stimulates the production of arachidonic acid metabolites and acts synergistically with other cytokines, particularly tumor necrosis factor.
Journal ArticleDOI
Microglia as a source and target of cytokines.
TL;DR: Strong responses and modulatory influences can be demonstrated, adding to the emerging view that microglial behavior is highly dependent on the (cytokine) environment and that reactions to a challenge may vary with the stimulation context.
Journal ArticleDOI
Characterization of ameboid microglia isolated from developing mammalian brain
D Giulian,TJ Baker +1 more
TL;DR: It is suggested that in vitro ameboid microglia differentiate into nonphagocytic cells similar to ramifiedmicroglia found in normal adult brain.
Journal ArticleDOI
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.
TL;DR: NIDDM is associated with an elevated acute-phase response, particularly in those with features of syndrome X, and abnormalities of the innate immune system may be a contributor to the hypertriglyceridaemia, low HDL cholesterol, hypertension, glucose intolerance, insulin resistance and accelerated atherosclerosis of NIDDM.
References
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Journal ArticleDOI
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
Carl J. March,Bruce Mosley,Larsen Alf D,Douglas P. Cerretti,Gary Braedt,Virginia L. Price,Steven Gillis,Christopher S. Henney,Shirley R. Kronheim,Kenneth H. Grabstein,Paul J. Conlon,Thomas P. Hopp,David Cosman +12 more
TL;DR: Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-lα and IL-1β), were isolated from a macrophage cDNA library.
Journal ArticleDOI
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.
Philip E. Auron,Andrew C. Webb,Lanny J. Rosenwasser,Steven F. Mucci,Alexander Rich,Sheldon M. Wolff,Charles A. Dinarello +6 more
TL;DR: The cDNA nucleotide sequence suggests that IL-1 is initially translated as a precursor molecule that is subsequently processed into the 15,000-20,000 Mr protein usually associated with IL- 1 activity.
Journal ArticleDOI
Function of macrophages in antigen recognition by guinea pig t lymphocytes : i. requirement for histocompatible macrophages and lymphocytes
TL;DR: The data demonstrate that efficient presentation of macrophage-associated antigen to the lymphocyte requires identity between macrophages and lymphocyte at some portion of the major histocompatibility complex.
Journal Article
Interleukin 1, a potential regulator of fibroblast proliferation.
Journal ArticleDOI
Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever.
TL;DR: It is suggested that cyclooxygenase inhibitors may be useful in the treatment of negative nitrogen balance in fever and the release of prostaglandin E2 induced by leukocytic pyrogen may account for the myalgia that accompanies fever.
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