Journal ArticleDOI
Liposomal Drug Delivery Systems: An Update Review
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TLDR
The new developments in this field are the specific binding properties of a drug-carrying liposome to a target cell such as a tumor cell and specific molecules in the body (antibodies, proteins, peptides etc).Abstract:
The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. Recently the liposome formulations are targeted to reduce toxicity and increase accumulation at the target site. There are several new methods of liposome preparation based on lipid drug interaction and liposome disposition mechanism including the inhibition of rapid clearance of liposome by controlling particle size, charge and surface hydration. Most clinical applications of liposomal drug delivery are targeting to tissue with or without expression of target recognition molecules on lipid membrane. The liposomes are characterized with respect to physical, chemical and biological parameters. The sizing of liposome is also critical parameter which helps characterize the liposome which is usually performed by sequential extrusion at relatively low pressure through polycarbonate membrane (PCM). This mode of drug delivery lends more safety and efficacy to administration of several classes of drugs like antiviral, antifungal, antimicrobial, vaccines, anti-tubercular drugs and gene therapeutics. Present applications of the liposomes are in the immunology, dermatology, vaccine adjuvant, eye disorders, brain targeting, infective disease and in tumour therapy. The new developments in this field are the specific binding properties of a drug-carrying liposome to a target cell such as a tumor cell and specific molecules in the body (antibodies, proteins, peptides etc.); stealth liposomes which are especially being used as carriers for hydrophilic (water soluble) anticancer drugs like doxorubicin, mitoxantrone; and bisphosphonate- liposome mediated depletion of macrophages. This review would be a help to the researchers working in the area of liposomal drug delivery.read more
Citations
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Journal ArticleDOI
Metal-organic frameworks in biomedicine.
Patricia Horcajada,Ruxandra Gref,Tarek Baati,Phoebe K. Allan,Guillaume Maurin,Patrick Couvreur,Gérard Férey,Russell E. Morris,Christian Serre +8 more
TL;DR: Metal Organic Frameworks in Biomedicine Patricia Horcajada, Ruxandra Gref, Tarek Baati, Phoebe K. Allan, Guillaume Maurin, Patrick Couvreur, G erard F erey, Russell E. Morris, and Christian Serre.
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Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology.
Kim E. Sapsford,W. Russ Algar,Lorenzo Berti,Kelly Boeneman Gemmill,Brendan J. Casey,Eunkeu Oh,Michael H. Stewart,Igor L. Medintz +7 more
TL;DR: Chemistries that Facilitate Nanotechnology Kim E. Sapsford,† W. Russ Algar, Lorenzo Berti, Kelly Boeneman Gemmill,‡ Brendan J. Casey,† Eunkeu Oh, Michael H. Stewart, and Igor L. Medintz .
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New Developments in Liposomal Drug Delivery.
TL;DR: Bhushan S. Pattni,† Vladimir V. Chupin,‡ and Vladimir P. Torchilin study the role of phosphorous in the biosynthesis of Membrane Proteins and found that phosphorous binds to polypeptide A in a manner similar to that of polymethine.
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A review on phospholipids and their main applications in drug delivery systems
TL;DR: Five types of carriers based on phospholipids are introduced, including liposomes, intravenous lipid emulsions, micelles, drug-phospholipid complexes and cochleates, to introduce their applications in drug delivery systems.
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Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions.
TL;DR: The understanding of the complex cellular and molecular processes involved in BRB leakage has grown rapidly in recent years and provided tools for rational design of drugs aimed at restoring the BRB as well as for design of effective transport of drugs across theBRB to treat the chronic retinal diseases.
References
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Book
Liposomes : a practical approach
TL;DR: Cossins liposomes in biological systems, R.R.C.Jones and A.J.Martin physical methods of study and new liposome characterization.
Journal ArticleDOI
Liposomes as drug carriers
TL;DR: The use of liposomes as drug carrying vehicles, introduction of smaller doses, increased permeability, reduced toxicological and allergic effects and altered immunological responses are the advantages of the method.
Book
Medical applications of liposomes
TL;DR: A comparison study of Liposomes in Medicine, Industrial Manufacturing and Pre-Clinical Testing, and other Applications finds that Liposome Pharmaceuticals have shown promise in both industrial manufacturing and clinical testing.