Journal ArticleDOI
Magnesium based degradable biomaterials: A review
TLDR
In this article, a comprehensive review of the development of representative magnesium-based alloys, including Mg-Ca, MgSr,Mg-Zn and MgREE, is presented.Abstract:
Magnesium has been suggested as a revolutionary biodegradable metal for biomedical applications. The corrosion of magnesium, however, is too rapid to match the rates of tissue healing and, additionally, exhibits the localized corrosion mechanism. Thus it is necessary to control the corrosion behaviors of magnesium for their practical use. This paper comprehensively reviews the research progress on the development of representative magnesium based alloys, including Mg-Ca, Mg-Sr, Mg-Zn and Mg-REE alloy systems as well as the bulk metallic glass. The influence of alloying element on their microstructures, mechanical properties and corrosion behaviors is summarized. The mechanical and corrosion properties of wrought magnesium alloys are also discussed in comparison with those of cast alloys. Furthermore, this review also covers research carried out in the field of the degradable coatings on magnesium alloys for biomedical applications. Calcium phosphate and biodegradable polymer coatings are discussed based on different preparation techniques used. We also compare the effect of different coatings on the corrosion behaviors of magnesium alloys substrate.read more
Citations
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Journal ArticleDOI
Advances in coatings on biodegradable magnesium alloys
Zheng-Zheng Yin,Wei-Chen Qi,Rong-Chang Zeng,Rong-Chang Zeng,Xiaobo Chen,Chang-Dong Gu,Shaokang Guan,Yufeng Zheng +7 more
TL;DR: In this paper, the authors reviewed the cutting-edge advances and progress of biodegradable surface coatings upon Mg alloys over the last decades, and aimed to build up a knowledge framework of surface modification on bioregradable Mg alloy.
Journal ArticleDOI
In Vitro Corrosion and Cytocompatibility of a Microarc Oxidation Coating and Poly(l-lactic acid) Composite Coating on Mg–1Li–1Ca Alloy for Orthopedic Implants
TL;DR: The results indicated that the MAO/PLLA composite coatings significantly enhanced the corrosion resistance of the Mg-1Li-1Ca alloy and may be appropriate for applications on degradable M g-based orthopedic implants.
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Research on a Zn-Cu alloy as a biodegradable material for potential vascular stents application.
TL;DR: In vitro evaluation shows that Zn-4Cu presents acceptable toxicity to human endothelial cells, and could effectively inhibit bacteria adhesion and biofilm formation, which make it an excellent candidate material for biodegradable implants, especially for cardiovascular stents application.
Journal ArticleDOI
Enhanced Corrosion Resistance and Biocompatibility of Magnesium Alloy by Mg-Al-Layered Double Hydroxide.
TL;DR: Mg(OH)2 coating containing Mg-Al LDH in the present study shows a promising application in improving anticorrosion and biocompatibility of Mg alloys, and might act as a platform for a further modification of M g alloys ascribed to its special layer structure.
Journal ArticleDOI
In vitro corrosion of as-extruded Mg–Ca alloys—The influence of Ca concentration
TL;DR: In this article, microstructure, composition and the corrosion resistance of Mg-Ca alloys were analyzed using SEM, EDS, XPS, EPMA, XRD, electrochemical and immersion tests.
References
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Journal ArticleDOI
Magnesium and its alloys as orthopedic biomaterials: a review.
TL;DR: A review of the properties, biological performance, challenges and future directions of magnesium-based biomaterials can be found in this paper, where the authors explore the properties and challenges of magnesium biomaterial.
Journal ArticleDOI
In vivo corrosion of four magnesium alloys and the associated bone response.
Frank Witte,Volker Kaese,Heinz Haferkamp,E. Switzer,Andrea Meyer-Lindenberg,Carl Joachim Wirth,H. Windhagen +6 more
TL;DR: There is a strong rationale that in this research model, high magnesium ion concentration could lead to bone cell activation, and metallic implants made of magnesium alloys degrade in vivo depending on the composition of the alloying elements.
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Corrosion mechanisms of magnesium alloys
Guang-Ling Song,Andrej Atrens +1 more
TL;DR: In this paper, a detailed review of the corrosion mechanisms of magnesium alloys is presented, and the basis for the design of new alloys with improved corrosion properties is provided for improving the corrosion properties.
Journal ArticleDOI
Degradable biomaterials based on magnesium corrosion
Frank Witte,Frank Witte,Norbert Hort,Carla Vogt,Smadar Cohen,Karl Ulrich Kainer,Regine Willumeit,Frank Feyerabend +7 more
TL;DR: Magnesium and its alloys have been investigated recently by many authors as a suitable biodegradable biomaterial as mentioned in this paper, and the latest achievements and comment on the selection and use, test methods and the approaches to develop and produce magnesium alloys that are intended to perform clinically with an appropriate host response.
Journal ArticleDOI
The development of binary Mg–Ca alloys for use as biodegradable materials within bone
TL;DR: The results of tensile tests and in vitro corrosion tests indicated that Mg-1Ca alloy had the acceptable biocompatibility as a new kind of biodegradable implant material and a solid alloy/liquid solution interface model was proposed to interpret the biocorrosion process and the associated hydroxyapatite mineralization.