Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-γ Activation
TLDR
The present review highlights the importance of curcumin as an anti-inflammatory agent and suggests that the beneficial effect ofCurcumin is mediated by the upregulation of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation.Abstract:
Curcumin, the phytochemical component in turmeric, is used as a dietary spice and a topical ointment for the treatment of inflammation in India for centuries. Curcumin (diferuloylmethane) is relatively insoluble in water, but dissolves in acetone, dimethylsulphoxide, and ethanol. Commercial grade curcumin contains 10–20% curcuminoids, desmethoxycurcumin, and bisdesmethoxycurcumin and they are as effective as pure curcumin. Based on a number of clinical studies in carcinogenesis, a daily oral dose of 3.6 g curcumin has been efficacious for colorectal cancer and advocates its advancement into Phase II clinical studies. In addition to the anticancer effects, curcumin has been effective against a variety of disease conditions in both in vitro and in vivo preclinical studies. The present review highlights the importance of curcumin as an anti-inflammatory agent and suggests that the beneficial effect of curcumin is mediated by the upregulation of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation.read more
Citations
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Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
Limei Wang,Birgit Waltenberger,Eva-Maria Pferschy-Wenzig,Martina Blunder,Xin Liu,Clemens Malainer,Tina Blazevic,Stefan Schwaiger,Judith M. Rollinger,Elke H. Heiss,Daniela Schuster,Brigitte Kopp,Rudolf Bauer,Hermann Stuppner,Verena M. Dirsch,Atanas G. Atanasov +15 more
TL;DR: A significant research effort has recently been undertaken to explore the PPARγ-activating potential of a wide range of natural products originating from traditionally used medicinal plants or dietary sources.
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