Journal ArticleDOI
Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog.
TLDR
Research into alpha(2) adrenoreceptor agonists and their clinical use is extensive, so emphasis is given to the cardiovascular effects and antinociceptive action of these agents.About:
This article is published in Veterinary Anaesthesia and Analgesia.The article was published on 2005-05-01. It has received 313 citations till now. The article focuses on the topics: Medetomidine & Dexmedetomidine.read more
Citations
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Journal ArticleDOI
Guidelines for recognition, assessment and treatment of pain: WSAVA Global Pain Council members and co-authors of this document:.
Karol Mathews,Peter W Kronen,Duncan Lascelles,Andrea M. Nolan,Sheilah A. Robertson,Paulo V. Steagall,Bonnie Wright,Kazuto Yamashita +7 more
TL;DR: This dissertation aims to provide a history ofVM education in the United States and Europe from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year of World War II.
Journal ArticleDOI
Recognition and Alleviation of Pain in Laboratory Animals
TL;DR: A broad range of pharmacological and non-pharmacological strategies to prevent or treat pain is described in depth and the important issue of humane endpoints is central to any strategy dedicated to reduce or avoid unnecessary pain and distress, without compromising the scientific validity of the studies.
Journal ArticleDOI
A protocol for use of medetomidine anesthesia in rats for extended studies using task-induced BOLD contrast and resting-state functional connectivity
Christopher P. Pawela,Bharat B. Biswal,Anthony G. Hudetz,Marie L. Schulte,Rupeng Li,Seth R. Jones,Younghoon R. Cho,Hani S. Matloub,James S. Hyde +8 more
TL;DR: The alpha-2-adrenoreceptor agonist, medetomidine, which exhibits dose-dependent sedative effects and is gaining acceptance in small-animal functional magnetic resonance imaging (fMRI), has been studied.
Journal ArticleDOI
An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.
TL;DR: Treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate not only resulting in resolution of brady Cardia but also resulting in an exaggerated increase of arterial blood pressure is reported on.
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A comparison of ketamine–midazolam and ketamine–medetomidine combinations for induction of anaesthesia in rabbits
Nicola J Grint,PJ Murison +1 more
TL;DR: In a randomized, prospective, blinded clinical trial of 50 rabbits undergoing ovariohysterectomy or castration, the mean time to loss of righting reflex (LRR), body mass, respiratory rate (RR), and arterial oxygen saturation of haemoglobin (SpO2) were compared using a two-tailed t-test as discussed by the authors.
References
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Journal ArticleDOI
Blood flow measurements with radionuclide-labeled particles.
TL;DR: The microsphere technique is relatively simple and extremely accurate when appropriately and correctly applied, and it can be used to quantify arteriovenous anastomoses as well as the measurement of organ blood flows and distribution of blood flow within those organs.
Journal Article
Presynaptic regulation of the release of catecholamines.
TL;DR: Evidence has accumulated in favour of the view that, in addition to the classical postsynaptic adrenoceptors that mediate the responses of the effector organ, there are also receptors located on the noradrenergic nerve terminals that appear to be involved in the modulation of the release of dopamine and of epinephrine in the central nervous system.
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The effects of increasing plasma concentrations of dexmedetomidine in humans.
TL;DR: In this article, the responses to increasing plasma concentrations of dexmedetomidine in humans were determined, and 10 healthy men (20-27 yr) provided informed consent and were monitored (underwent electrocardiography, measured arterial, central venous [CVP] and pulmonary artery [PAP] pressures,
Journal ArticleDOI
Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
S Arnér,B A Meyerson +1 more
TL;DR: The outcome of the double‐blind opioid test has proved useful to justify a continued, or discontinued, use of narcotic medication in individual patients and may also support the indication and choice of invasive stimulation procedures (spinal cord or brain).
Related Papers (5)
Hemodynamic effects of medetomidine in the dog: a dose titration study.
Bruno H Pypendop,John Verstegen +1 more