Journal ArticleDOI
Methods for evaluation of medication adherence and persistence using automated databases.
TLDR
The aim was to perform a systematic review of the methods currently being used to assess adherence and persistence in pharmacoepidemiological and pharmacoeconomic studies using automated databases.Abstract:
Purpose
Our aim was to perform a systematic review of the methods currently being used to assess adherence and persistence in pharmacoepidemiological and pharmacoeconomic studies using automated databases.
Methods
A MEDLINE search of English language literature was performed to identify studies published between January 1, 1980 and March 31, 2004 that evaluated adherence, compliance, persistence, switching, or discontinuations of medications using automated dispensing data (pharmacy records). Two study investigators independently reviewed the abstracts and articles to determine relevant studies according to specified criteria.
Results
A total of 136 articles met the criteria for evaluation. The types of measures of adherence and persistence commonly reported include the medication possession ratio and related measures of medication availability (77 studies), discontinuation/continuation (58 studies), switching (34 studies), medication gaps (13 studies), refill compliance (7 studies), and retentiveness/turbulence (4 studies). Specific issues considered include the assessment of exposed time to drug therapy and specification of the follow-up period.
Conclusions
The terminology, definitions, and methods to determine adherence and persistence differ greatly in the published literature. The appropriateness and choice of the specific measure employed should be determined by the overall goals of the study, as well as the relative advantages and limitations of the measures. Copyright © 2006 John Wiley & Sons, Ltd.read more
Citations
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Journal ArticleDOI
Medication Adherence: Its Importance in Cardiovascular Outcomes
TL;DR: The goals of the present report are to address different methods of measuring adherence, the prevalence of medicationNonadherence, the association between nonadherence and outcomes, the reasons for nonad adherence, and finally, interventions to improve medication adherence.
Journal ArticleDOI
A new taxonomy for describing and defining adherence to medications
Bernard Vrijens,Sabina De Geest,Sabina De Geest,Dyfrig A. Hughes,Kardas Przemyslaw,Jenny Demonceau,Todd M. Ruppar,Todd M. Ruppar,Fabienne Dobbels,E.A. Fargher,Val Morrison,Paweł Lewek,Michał Matyjaszczyk,Comfort Mshelia,Wendy Clyne,Jeffrey K Aronson,John Urquhart +16 more
TL;DR: In response to the proliferation of ambiguous or unquantifiable terms in the literature on medication adherence, this research has resulted in a new conceptual foundation for a transparent taxonomy, focused on promoting consistency and quantification in terminology and methods.
Journal ArticleDOI
Medication Adherence Measures: An Overview
Wai Yin Lam,Paula Fresco +1 more
TL;DR: Both subjective and objective medication adherence measures are reviewed, including direct measures, those involving secondary database analysis, electronic medication packaging devices, pill count, and clinician assessments and self-report.
Journal ArticleDOI
Early Discontinuation and Nonadherence to Adjuvant Hormonal Therapy in a Cohort of 8,769 Early-Stage Breast Cancer Patients
Dawn L. Hershman,Lawrence H. Kushi,Theresa Shao,Donna Buono,Aaron Kershenbaum,Wei-Yann Tsai,Louis Fehrenbacher,Scarlett Lin Gomez,Sunita Miles,Alfred I. Neugut +9 more
TL;DR: Younger or older age, lumpectomy (v mastectomy), and comorbidities were associated with earlier discontinuation, while Asian race, being married, earlier year at diagnosis, receipt of chemotherapy or radiotherapy, and longer prescription refill interval wereassociated with completion of 4.5 years of therapy.
Journal ArticleDOI
Adherence to Antihypertensive Medications and Cardiovascular Morbidity Among Newly Diagnosed Hypertensive Patients
Giampiero Mazzaglia,Ettore Ambrosioni,Marianna Alacqua,Alessandro Filippi,Emiliano Sessa,V. Immordino,Claudio Borghi,Ovidio Brignoli,Achille P. Caputi,Claudio Cricelli,Lorenzo G. Mantovani +10 more
TL;DR: The long-term reduction of acute cardiovascular events associated with high adherence to antihypertensive treatment underscores its importance in assessments of the beneficial effects of evidence-based therapies in the population.
References
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Journal ArticleDOI
Patient adherence to treatment: three decades of research: a comprehensive review
TL;DR: Relevant studies were retrieved through comprehensive searches of different database systems to enable a thorough assessment of the major issues in compliance to prescribed medical interventions.
Journal ArticleDOI
Depression and diabetes: impact of depressive symptoms on adherence, function, and costs.
TL;DR: In this article, the authors explored the impact of depressive symptoms in primary care patients with diabetes on self-care, adherence to medication regimens, functioning, and health care costs.
Journal ArticleDOI
The assessment of refill compliance using pharmacy records: Methods, validity, and applications
TL;DR: It is concluded that, though some methodologic problems require further study, RC measures can be a useful source of compliance information in population-based studies when direct measurement of medication consumption is not feasible.
Journal ArticleDOI
A Systematic Review of Adherence With Medications for Diabetes
TL;DR: It is confirmed that many patients for whom diabetes medication was prescribed were poor compliers with treatment, including both OHAs and insulin, however, electronic monitoring systems were useful in improving adherence for individual patients.
Journal ArticleDOI
Measurement, Correlates, and Health Outcomes of Medication Adherence Among Seniors
TL;DR: A comprehensive review of the literature on the measurement, correlates, and health outcomes of medication adherence among community-dwelling older adults suggests polypharmacy and poor patient–healthcare provider relationships may be major determinants of nonadherence among older persons.