MicroRNA therapeutics: Discovering novel targets and developing specific therapy.
Ajay Francis Christopher,Raman Preet Kaur,Gunpreet Kaur,Amandeep Kaur,Vikas Gupta,Parveen Bansal +5 more
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TLDR
A large number of miRNAs have entered the preclinical and clinical stage and soon might be available in the market for use in humans, and many more are in the development stage.Abstract:
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression in diverse biological process. They act as intracellular mediators that are necessary for various biological processes. MicroRNAs targeting pathways of human disease provide a new and potential powerful candidate for therapeutic intervention against various pathological conditions. Even though, the information about miRNA biology has significantly enriched but we still do not completely understand the mechanism of miRNA gene regulation. Various groups across the globe and pharmaceutical companies are conducting research and developments to explore miRNA based therapy and build a whole new area of miroRNA therapeutics. Consequently, few miRNAs have entered the preclinical and clinical stage and soon might be available in the market for use in humans.read more
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Journal ArticleDOI
Advances in the delivery of RNA therapeutics: from concept to clinical reality.
TL;DR: The challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies, are discussed, and an overview of the applications of RNAs for modulation of gene/protein expression and genome editing that are currently being investigated both in the laboratory as well as in the clinic are presented.
Journal ArticleDOI
Inflammasome Priming in Sterile Inflammatory Disease.
Meghana N. Patel,Richard G. Carroll,Silvia Galván-Peña,Silvia Galván-Peña,Evanna L. Mills,Evanna L. Mills,Robin Olden,Martha Triantafilou,Martha Triantafilou,Amaya I. Wolf,Clare E. Bryant,Kathy Triantafilou,Kathy Triantafilou,Seth L. Masters,Seth L. Masters,Seth L. Masters +15 more
TL;DR: It is now clear that inflammasomes are activated during the progression of sterile inflammatory diseases such as atherosclerosis, metabolic disease, and neuroinflammatory disorders, and it is time to consider the endogenous factors and mechanisms that may prime the inflammaome in these conditions.
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MicroRNAs: Roles in Regulating Neuroinflammation:
TL;DR: The role of miRNAs in neuroinflammatory regulation is discussed and how controlling miRNA-based therapeutic manipulations could alter cellular machinery to improve neuroinflammatory dynamics is discussed.
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miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target.
Marcin Serocki,Sylwia Bartoszewska,Anna Janaszak-Jasiecka,Renata Ochocka,James F. Collawn,Rafal Bartoszewski +5 more
TL;DR: The significance of the microRNAs on the relationship between the HIFs under both physiological and pathophysiological conditions is reviewed and miRNAs that endogenously regulate gene expression via the RNA interference pathway are shown to play critical roles in the hypoxia response pathways.
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Role of microRNAs in obesity and obesity-related diseases
Giuseppe Iacomino,Alfonso Siani +1 more
TL;DR: The status of current research on the role of miRNAs in obesity and related metabolic abnormalities is summarized and discussed.