Journal ArticleDOI
Molecular diversity of spirooxindoles. Synthesis and biological activity
TLDR
This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.Abstract:
Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.read more
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Catalytic asymmetric synthesis of spirooxindoles: recent developments
Guang-Jian Mei,Feng Shi +1 more
TL;DR: This feature article outlines the recent progress in the catalytic asymmetric synthesis of spirooxindoles, including the contributions of the group of scientists from the University of California, Berkeley.
Journal ArticleDOI
Supported molybdenum on graphene oxide/Fe3O4: An efficient, magnetically separable catalyst for one-pot construction of spiro-oxindole dihydropyridines in deep eutectic solvent under microwave irradiation
TL;DR: Magnetically separable graphene oxide supported molybdenum (Fe 3 O 4 /GO-Mo) nanoparticles were prepared and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), TEM, Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometry (VSM) techniques as discussed by the authors.
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Enantioselective Synthesis of C-N Axially Chiral N-Aryloxindoles by Asymmetric Rhodium-Catalyzed Dual C-H Activation.
TL;DR: The first enantioselective Satoh-Miura-type reaction is reported, and it is also the first example of the asymmetric synthesis of C-N axially chiral compounds by such a C-H activation strategy.
Journal ArticleDOI
An overview of spirooxindole as a promising scaffold for novel drug discovery.
TL;DR: An overview of different applications and developments of spirooxindoles (including the related natural products and their derivatives) in the process of drug innovation, including such as in anticancer, antimicrobial, anti–inflammatory, analgesic, antioxidant, antimalarial, and antiviral activities is offered.
Journal ArticleDOI
Catalyst-Free, Visible-Light Promoted One-Pot Synthesis of Spirooxindole-Pyran Derivatives in Aqueous Ethyl Lactate
TL;DR: In this article, a highly efficient, eco-friendly protocol has been developed for synthesis of spirooxindole-pyran derivatives via one-pot, three-component reaction of isatins, malononitrile, and enolizable C-H activated compounds (2-hydroxynaphthalene-1,4-dione, 4-hydroxycoumarine and dimedone).
References
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Journal ArticleDOI
Target-oriented and diversity-oriented organic synthesis in drug discovery.
TL;DR: Several synthetic planning principles for diversity-oriented synthesis and their role in the drug discovery process are presented in this review.
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Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks
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Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids
TL;DR: The spiro[pyrrolidine-3,3′-oxindole] ring system is found at the core of a number of alkaloids, which possess significant biological activity and are interesting, challenging targets for chemical synthesis as discussed by the authors.