National Institute for the Infectious Diseases "L. Spallanzani", IRCCS. Recommendations for COVID-19 clinical management.
Emanuele Nicastri,Nicola Petrosillo,Tommaso Ascoli Bartoli,Luciana Lepore,Annalisa Mondi,Fabrizio Palmieri,Gianpiero D'Offizi,Luisa Marchioni,Silvia Murachelli,Giuseppe Ippolito,Andrea Antinori +10 more
TLDR
Recommendations for the management of COVID-19 patients are shown, based on very limited clinical evidences, which should be considered as expert opinions, which may be modified according to newly produced literature data.Abstract:
On January 9 2020, the World Health Organization (WHO) declared the identification, by Chinese Health authorities, of a novel coronavirus, further classified as SARS-CoV-2 responsible of a disease (COVID-19) ranging from asymptomatic cases to severe respiratory involvement. On March 9 2020, WHO declared COVID-19 a global pandemic. Italy is the second most affected country by COVID-19 infection after China. The "L. Spallanzani" National Institute for the Infectious Diseases, IRCCS, Rome, Italy, has been the first Italian hospital to admit and manage patients affected by COVID-19. Hereby, we show our recommendations for the management of COVID-19 patients, based on very limited clinical evidences; they should be considered as expert opinions, which may be modified according to newly produced literature data.read more
Citations
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Drug repurposing approach to fight COVID-19.
Thakur Uttam Singh,Subhashree Parida,Madhu Cholenahalli Lingaraju,Manickam Kesavan,Dinesh Kumar,Raj Kumar Singh +5 more
TL;DR: The present review will focus on the repurposing efficacy of the currently used drugs against COVID-19 and their mechanisms of action, pharmacokinetics, dosing, safety, and their future perspective.
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The neurological manifestations of COVID-19: a review article.
TL;DR: Various evidences support the possible CNS roles in the COVID-19 pathophysiology and further investigation of CNS involvement of SARS-COV-2 is suggested.
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COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome?
TL;DR: This review analyzes the possible epidemiological and molecular mechanisms responsible for hyper-inflammation in patients with severe COVID-19 and underline the similarities between this condition and “hyperferritinemic syndromes” which would allow considering this entity as the fifth member of the spectrum of inflammatory conditions.
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COVID-19 and the clinical hematology laboratory.
TL;DR: The laboratory's role in the diagnosis of COVID‐19 infection is discussed, the current state of biomarker analysis in COVID'S infection is summarized, and the impact of the pandemic has had on organized national and international educational activities worldwide is described.
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Sex difference in coronavirus disease (COVID-19): a systematic review and meta-analysis.
Biruk Beletew Abate,Ayelign Mengesha Kassie,Mesfin Wudu Kassaw,Teshome Gebremeskel Aragie,Setamlak Adane Masresha +4 more
TL;DR: The prevalence of symptomatic COVID-19 was found to be higher in men than in women, and the high prevalence of smoking and alcohol consumption contributed to thehigh prevalence of CO VID-19 among men.
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