Journal ArticleDOI
Neonicotinoids—from zero to hero in insecticide chemistry
Peter Jeschke,Ralf Nauen +1 more
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TLDR
This review comprehensively describes particularly the origin, structure and bonding as well as associated properties of neonicotinoid insecticides.Abstract:
In recent years, neonicotinoids have been the fastest-growing class of insecticides in modern crop protection, with widespread use against a broad spectrum of sucking and certain chewing pests As potent agonists, they act selectively on insect nicotinic acetylcholine receptors, their molecular target site The discovery of neonicotinoids can be considered as a milestone in insecticide research and facilitates greatly the understanding of the functional properties of insect nicotinic acetylcholine receptors Because of the relatively low risk for non-target organisms and environment, the high target specificity of neonicotinoid insecticides and their versatility in application methods, this important class has to be maintained globally for integrated pest management strategies and insect resistance management programmes This review comprehensively describes particularly the origin, structure and bonding as well as associated properties of neonicotinoid insecticidesread more
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Journal ArticleDOI
Overview of the Status and Global Strategy for Neonicotinoids
TL;DR: The crystal structure of the acetylcholine-binding proteins provides the theoretical foundation for designing homology models of the corresponding receptor ligand binding domains within the nAChRs, a useful basis for virtual screening of chemical libraries and rational design of novel insecticides acting on these practically relevant channels.
Journal ArticleDOI
Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites
Noa Simon-Delso,Noa Simon-Delso,V. Amaral-Rogers,Luc P. Belzunces,Jean-Marc Bonmatin,Madeleine Chagnon,Craig A. Downs,Lorenzo Furlan,David W. Gibbons,Chiara Giorio,Vincenzo Girolami,Dave Goulson,David P. Kreutzweiser,Christian H. Krupke,Matthias Liess,Elizabeth Y. Long,Melanie McField,Pierre Mineau,Edward A. D. Mitchell,Christy A. Morrissey,D. A. Noome,L. Pisa,Josef Settele,John D. Stark,Andrea Tapparo,H Van Dyck,J. van Praagh,J.P. van der Sluijs,J.P. van der Sluijs,Penelope R. Whitehorn,Martin Wiemers +30 more
TL;DR: In this paper, a review of the global literature explores these risks and show a growing body of evidence that persistent, low concentrations of these insecticides pose serious risks of undesirable environmental impacts.
Journal ArticleDOI
Chemical Pesticides and Human Health: The Urgent Need for a New Concept in Agriculture.
P. Nicolopoulou-Stamati,Sotirios Maipas,Chrysanthi Kotampasi,Panagiotis J. Stamatis,Luc Hens +4 more
TL;DR: It is more obvious than ever that the society needs the implementation of a new agricultural concept regarding food production, which is safer for man and the environment, and to this end, steps such as the declaration of Nyéléni have been taken.
Journal ArticleDOI
Environmental fate and exposure; neonicotinoids and fipronil
Jean-Marc Bonmatin,Chiara Giorio,Vincenzo Girolami,Dave Goulson,David P. Kreutzweiser,Christian H. Krupke,Matthias Liess,Elizabeth Y. Long,Matteo Marzaro,Edward A. D. Mitchell,D. A. Noome,Noa Simon-Delso,Andrea Tapparo +12 more
TL;DR: There is strong evidence that soils, waterways, and plants in agricultural environments and neighboring areas are contaminated with variable levels of neonicotinoids or fipronil mixtures and their metabolites, and this provides multiple routes for chronic exposure of nontarget animals.
Journal ArticleDOI
Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: A review
Christy A. Morrissey,Pierre Mineau,James H. Devries,Francisco Sánchez-Bayo,Matthias Liess,Michael C. Cavallaro,Karsten Liber +6 more
TL;DR: It appears that environmentally relevant concentrations of neonicotinoids in surface waters worldwide are well within the range where both short- and long-term impacts on aquatic invertebrate species are possible over broad spatial scales.
References
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Journal ArticleDOI
Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.
Katjuša Brejc,W.J. van Dijk,Remco V. Klaassen,M. Schuurmans,J. van der Oost,J. van der Oost,August B. Smit,Titia K. Sixma +7 more
TL;DR: The crystal structure of molluscan acetylcholine-binding protein (AChBP), a structural and functional homologue of the amino-terminal ligand-binding domain of an nAChR α-subunit, is presented and is relevant for the development of drugs against Alzheimer’s disease and nicotine addiction.
Journal ArticleDOI
Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution
TL;DR: A comparison of the structure of the alpha subunit with that of AChBP having ligand present, suggests how the localised rearrangement overcomes the distortions and initiates the rotational movements associated with opening of the channel.
Journal ArticleDOI
NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more
TL;DR: The neonicotinoids have outstanding potency and systemic action for crop protection against piercing-sucking pests, and they are highly effective for flea control on cats and dogs.
Journal ArticleDOI
Relationships between lipophilicity and root uptake and translocation of non-ionised chemicals by barley†
TL;DR: In this article, the uptake by roots from solution, and subsequent translocation to shoots in barley, of two series of non-ionised chemicals, O-methylcarbamoyloximes and substituted phenylureas, were measured, Uptake of the chemicals by roots was greater the more lipophilic the chemical, and fell to a lower limiting value for polar chemicals.
Journal ArticleDOI
Selective toxicity of neonicotinoids attributable to specificity of insect and mammalian nicotinic receptors
Motohiro Tomizawa,John E. Casida +1 more
TL;DR: Knowledge reviewed here of the functional architecture and molecular aspects of the insect and mammalian nAChRs and their neonicotinoid-binding site lays the foundation for continued development and use of this new class of safe and effective insecticides.
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NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action
Motohiro Tomizawa,John E. Casida +1 more
Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites
Noa Simon-Delso,Noa Simon-Delso,V. Amaral-Rogers,Luc P. Belzunces,Jean-Marc Bonmatin,Madeleine Chagnon,Craig A. Downs,Lorenzo Furlan,David W. Gibbons,Chiara Giorio,Vincenzo Girolami,Dave Goulson,David P. Kreutzweiser,Christian H. Krupke,Matthias Liess,Elizabeth Y. Long,Melanie McField,Pierre Mineau,Edward A. D. Mitchell,Christy A. Morrissey,D. A. Noome,L. Pisa,Josef Settele,John D. Stark,Andrea Tapparo,H Van Dyck,J. van Praagh,J.P. van der Sluijs,J.P. van der Sluijs,Penelope R. Whitehorn,Martin Wiemers +30 more