Journal ArticleDOI
Nerve repair by means of tubulization: literature review and personal clinical experience comparing biological and synthetic conduits for sensory nerve repair.
TLDR
Different tubulization techniques proposed so far are described, focusing in particular on studies that reported on the employment of tubes with patients, and the clinical results are compared.Abstract:
Nerve repair is usually accomplished by direct suture when the two stumps can be approximated without tension. In the presence of a nerve defect, the placement of an autologous nerve graft is the current gold standard for nerve restoration. However, over the last 20 years, an increasing number of research articles reported on the use of non-nervous tubes (tubulization) for repairing nerve defects. The clinical employment of tubes (both biological and synthetic) as an alternative to autogenous nerve grafts is mainly justified by the limited availability of donor tissue for nerve autografts and the related morbidity. In addition, tubulization was proposed as an alternative to direct nerve sutures in order to create optimal conditions for nerve regeneration over the short empty space intentionally left between two nerve stumps. This paper outlines recent important advances in this field. Different tubulization techniques proposed so far are described, focusing in particular on studies that reported on the employment of tubes with patients. Our personal clinical experience on tubulization repair of sensory nerve lesions (digital nerves), using both biological and synthetic tubes, is presented, and the clinical results are compared. In our case series, both types of tubes led to good clinical results. Finally, we speculate about the prospects in the clinical application of tubulization for peripheral nerve repair.read more
Citations
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Journal ArticleDOI
FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacy
S. Kehoe,X.F. Zhang,Daniel Boyd +2 more
TL;DR: A comprehensive reference for clinicians which may facilitate optimal material/device selection for peripheral nerve repair and for materials scientists, this review highlights predicate devices and evaluation methodologies, offering an insight into current deficiencies associated with state-of-the-art materials.
Journal ArticleDOI
Schwann Cells: Development and Role in Nerve Repair
TL;DR: The signals that control the embryonic phase of this process and the organogenesis of peripheral nerves are described and the phenotypic plasticity retained by mature Schwann cells is discussed.
Journal ArticleDOI
Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration
TL;DR: Different nerve grafts used for peripheral nerve repair are summarized, various basic components of tissue engineered nerve grafting are highlighted in terms of their structures, features, and nerve regeneration-promoting actions, and current clinical applications and future perspectives are discussed.
Journal ArticleDOI
Neural tissue engineering options for peripheral nerve regeneration
TL;DR: New attempts in the design of template (or scaffold) materials are delineated, especially in the context of biocompatibility, the choice and handling of support cells, and growth factor release systems, to create a self-consistent coordinated system with a close proximity to the regenerative microenvironment of the peripheral nervous system.
Journal ArticleDOI
Repairing injured peripheral nerves: Bridging the gap
Ronald Deumens,Ahmet Bozkurt,Marcel F Meek,Marco A. E. Marcus,Marco A. E. Marcus,Elbert A.J. Joosten,Elbert A.J. Joosten,Joachim Weis,Joachim Weis,Gary A. Brook,Gary A. Brook +10 more
TL;DR: The developments in bridging technology which aim to replace the autograft are described, which are of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries.
References
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Journal ArticleDOI
Development of an upper extremity outcome measure: The DASH (disabilities of the arm, shoulder, and head)
TL;DR: The goal is to produce a brief, self-administered measure of symptoms and functional status, with a focus on physical function, to be used by clinicians in daily practice and as a research tool.
Journal ArticleDOI
Neural tissue engineering: strategies for repair and regeneration.
TL;DR: The nervous system physiology, the factors that are critical for nerve repair, and the current approaches that are being explored to aid peripheral nerve regeneration and spinal cord repair are reviewed.
Book
Surgical Disorders of The Peripheral Nerves
TL;DR: A cleaning system and method includes a screen for removing lint and other large solids from cleaning solvents and control means controls the discharge rate of the solvent from the receptacle, either in response to the liquid level in the sump or to the flow rates of the liquid being returned to the receptacles.
Journal Article
Erratum: Development of an upper extremity outcome measure: The DASH (Disabilities of the Arm, Shoulder, and Hand) (American Journal of Industrial Medicine (1996) 29:6 (602-608))
Pamela Hudak,Peter C. Amadio,Claire Bombardier,Dorcas E. Beaton,Donald C. Cole,Aileen M. Davis,G.A. Hawker,Jeffrey N. Katz,M. Makela,Robert G. Marx,Laura Punnett,James G. Wright +11 more
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