Neurogenic bladder in spinal cord injury patients.
Waleed Al Taweel,Raouf M. Seyam +1 more
TLDR
The current literature pertaining to the pathology and management of neurogenic bladder dysfunction in patients with spinal cord injury is summarized.Abstract:
Neurogenic bladder dysfunction due to spinal cord injury poses a significant threat to the well-being of patients. Incontinence, renal impairment, urinary tract infection, stones, and poor quality of life are some complications of this condition. The majority of patients will require management to ensure low pressure reservoir function of the bladder, complete emptying, and dryness. Management typically begins with anticholinergic medications and clean intermittent catheterization. Patients who fail this treatment because of inefficacy or intolerability are candidates for a spectrum of more invasive procedures. Endoscopic managements to relieve the bladder outlet resistance include sphincterotomy, botulinum toxin injection, and stent insertion. In contrast, patients with incompetent sphincters are candidates for transobturator tape insertion, sling surgery, or artificial sphincter implantation. Coordinated bladder emptying is possible with neuromodulation in selected patients. Bladder augmentation, usually with an intestinal segment, and urinary diversion are the last resort. Tissue engineering is promising in experimental settings; however, its role in clinical bladder management is still evolving. In this review, we summarize the current literature pertaining to the pathology and management of neurogenic bladder dysfunction in patients with spinal cord injury.read more
Citations
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Journal ArticleDOI
Traumatic spinal cord injury
Christopher S. Ahuja,Jefferson R. Wilson,Satoshi Nori,Mark R. N. Kotter,Claudia Druschel,Armin Curt,Michael G. Fehlings,Michael G. Fehlings +7 more
TL;DR: Several animal models and complementary behavioural tests of SCI have been developed to mimic this pathological process and form the basis for the development of preclinical and translational neuroprotective and neuroregenerative strategies.
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Assessment and management of acute spinal cord injury: From point of injury to rehabilitation.
TL;DR: In this article, the authors outline the pathophysiology, management, and long-term rehabilitation of individuals with traumatic spinal cord injury (SCI) and provide an in-depth overview of emerging therapies along the spectrum of the translational pipeline.
Journal ArticleDOI
The clinical diagnosis and management of urinary tract infections in children and adolescents
TL;DR: This manuscript reviews the diagnosis and management of acute and recurrent UTI in the paediatric and adolescent populations and proposes new treatment and prevention strategies.
Journal ArticleDOI
Update on critical care for acute spinal cord injury in the setting of polytrauma.
John K. Yue,Ethan A. Winkler,Ethan A. Winkler,Jonathan Rick,Jonathan Rick,Hansen Deng,Hansen Deng,Carlene P Partow,Carlene P Partow,Pavan S. Upadhyayula,Harjus Birk,Andrew K Chan,Andrew K Chan,Sanjay S. Dhall,Sanjay S. Dhall +14 more
TL;DR: The current review evaluates existing guidelines and updates the evidence for prehospital transport, immobilization, initial resuscitation, critical care, hemodynamic stability, diagnostic imaging, surgical techniques, and timing appropriate for the patient with SCI who has multisystem trauma.
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Antimicrobial prophylaxis for urinary tract infection in persons with spinal cord dysfunction.
TL;DR: The authors queried experts about possible unpublished studies, but none were identified, and 'grey' literature, such as letters and conference abstracts, was not excluded.
References
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Tissue-engineered autologous bladders for patients needing cystoplasty
TL;DR: Engineered bladder tissues, created with autologous cells seeded on collagen-polyglycolic acid scaffolds, and wrapped in omentum after implantation, can be used in patients who need cystoplasty.
Journal ArticleDOI
The neural control of micturition
TL;DR: The neural control of micturition is reviewed and how disruption of this control leads to abnormal storage and release of urine.
Journal ArticleDOI
Prognostic Value of Urodynamic Testing in Myelodysplastic Patients
Edward J. McGuire,Edward J. McGuire,Jeffrey R. Woodside,Jeffrey R. Woodside,Thomas A. Borden,Thomas A. Borden,Robert M. Weiss,Robert M. Weiss +7 more
TL;DR: Assessment of urethral function showed 36 patients (86 per cent) with an open vesical outlet and nonfunctional proximal urethra and 7 of 42 patients had reflex detrusor activity: 4 with coordinated micturition and 3 withdetrusor-sphincter dyssynergia.
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Botulinum-a toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? preliminary results
TL;DR: Botulinum-A toxin injections into the detrusor muscle seem to be a safe and valuable therapeutic option in spinal cord injured patients with incontinence resistant to anticholinergic medication who perform clean intermittent self-catheterization.
Journal ArticleDOI
Botulinum toxin type A is a safe and effective treatment for neurogenic urinary incontinence: results of a single treatment, randomized, placebo controlled 6-month study.
Brigitte Schurch,Marianne de Sèze,Pierre Denys,Emmanuel Chartier-Kastler,François Haab,Karel Everaert,Pierre Plante,Brigitte Perrouin-Verbe,Catherine Kumar,S Fraczek,Mitchell F. Brin +10 more
TL;DR: Intramuscular injections of BTX-A into the detrusor can provide rapid, well tolerated, clinically significant decreases in the signs and symptoms of urinary incontinence caused by neurogenicdetrusor overactivity during a 24-week study period.