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Open AccessJournal ArticleDOI

Nonmelanoma skin cancer

TLDR
The aetiology, diagnosis and management of NMSC are reviewed and metastasis from high-risk SCC may be fatal.
Abstract
Nonmelanoma skin cancer (NMSC) represents the most common form of cancer in Caucasians, with continuing increase in incidence worldwide. Basal cell carcinoma (BCC) accounts for 75% of cases of NMSC, and squamous cell carcinoma (SCC) accounts for the remaining majority of NMSC cases. Whilst metastasis from BCC is extremely rare, metastasis from high-risk SCC may be fatal. In this article, we review the aetiology, diagnosis and management of NMSC.

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Journal ArticleDOI

Oxidative Stress in Aging Human Skin

TL;DR: In this review the overall effects of oxidative stress are discussed as well as the sources of ROS including the mitochondrial ETC, peroxisomal and ER localized proteins, the Fenton reaction, and such enzymes as cyclooxygenase, lipoxygenases, xanthine oxidases, and NADPH oxidases.
Journal ArticleDOI

Non-melanoma skin cancer incidence and impact of skin cancer screening on incidence

TL;DR: The impact of screening on NMSC incidence in Schleswig-Holstein is analyzed by comparing four time periods of different screening settings to a reference region (Saarland, Germany) to provide up-to-date incidence estimates by sex, age group, histological type, and body site.
Journal ArticleDOI

Trends in Basal Cell Carcinoma Incidence Rates: A 37-Year Dutch Observational Study

TL;DR: In the absence of reliable tumor-based rates, these alarming patient-based BCC incidence rates are probably an interesting indicator for the impact of more intensive UV exposure in a prosperous European population.

Product monograph including patient medication information

TL;DR: OCREVUS® has been issued marketing authorization with conditions, pending the generation of additional data to further support the promising evidence of clinical benefit demonstrated in the PPMS pivotal study WA25046.
Journal ArticleDOI

The global burden of skin cancer: A longitudinal analysis from the Global Burden of Disease Study, 1990-2017.

TL;DR: The incidence, prevalence, and DALYs of skin cancers are increasing disproportionately among different demographic groups, and the GBD 2017 provides frequently updated measures of the skin cancer burden, which may help to direct resources and allocate funding to close the gap in global skin cancer disparities.
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