Journal ArticleDOI
Noteworthy Secondary Metabolites Naphthoquinones – their Occurrence, Pharmacological Properties and Analysis
TLDR
The utilizing of naphthoquinones for medicinal purposes and their occurrence in nature is reviewed and discussed and analytical techniques using for their analysis are reviewed.Abstract:
Chemical investigation of many bacterial and fungal, as well as plant species has revealed the presence of in- teresting compounds derived from naphthalene - 1,4-naphthoquinones and rarely also 1,2-naphthoquinones. They were detected in many species of families Bignoniaceae, Droseraceae, Plumbaginace, Boraginaceae, Juglandaceae as well as in species of small families, such as Dioncophyllaceae or Acanthaceae. Naphthoquinones have very interesting spectrum of biological actions, including antibiotic, antiviral, anti-inflammatory, antipyretic, antiproliferative and cytotoxic effects. Because of these properties the plants containing them are used in folk medicines, mainly by natives in Asia, where espe- cially Chinese medicine uses aerial as well as subterranean parts of these plants for hundreds years, and South America. The utilizing of naphthoquinones for medicinal purposes and their occurrence in nature is reviewed and discussed. Moreover, we review analytical techniques using for their analysis.read more
Citations
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Journal ArticleDOI
Plant phenolics: recent advances on their biosynthesis, genetics, and ecophysiology.
TL;DR: In the rhizosphere, increasing evidence suggests that root specific chemicals (exudates) might initiate and manipulate biological and physical interactions between roots and soil organisms, and one-way signals that relate the nature of chemical and physical soil properties to the roots.
Book ChapterDOI
Phenolic Compounds: Introduction
TL;DR: The ability to synthesize phenolic compounds has been selected throughout the course of evolution in different plant lineages, thus permitting plants to cope with the constantly changing environmental challenges over evolutionary time.
Journal ArticleDOI
Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants.
Joshua R. Widhalm,David Rhodes +1 more
TL;DR: In this review, the current understanding of the core metabolic pathways leading to plant 1,4-NQs is provided with additional emphasis on downstream natural products originating from horticultural species.
Journal ArticleDOI
Shikonin derivatives for cancer prevention and therapy
TL;DR: Shikonin exerts additive and synergistic interactions in combination with established chemotherapeutics, immunotherapeutic approaches, radiotherapy and other treatment modalities, which further underscores the potential of this phytochemical to be integrated into standard treatment regimens.
Journal ArticleDOI
Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications.
Chatragadda Ramesh,Nambali Valsalan Vinithkumar,Ramalingam Kirubagaran,Chidambaram Kulandaisamy Venil,Laurent Dufossé +4 more
TL;DR: This review has been made to provide overall knowledge on biodiversity, distribution, pathogenicity, and ecological and industrial applications of microbial pigments as well as their challenges and future directions for food, industrial, and biomedical applications.
References
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Journal ArticleDOI
Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis
TL;DR: In this paper, the authors discuss the role of genes and proteins in the development and regulation of MP BIOSYNTHESIS, including regulation by metabolites, regulation by Orotic Acid and Orotidine Accumulation.
Journal ArticleDOI
Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-κB Activation and NF-κB-regulated Gene Products Through Modulation of p65 and IκBα Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents
TL;DR: It is found that plumbagin inhibited NF-κB activation induced by TNF, and other carcinogens and inflammatory stimuli (e.g. phorbol 12-myristate 13-acetate, H2O2, cigarette smoke condensate, interleukin-1β, lipopolysaccharide, and okadaic acid).
Journal ArticleDOI
Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes
TL;DR: The findings indicate that topical preparations containing juglone and plumbagin should be used with care as their use may damage the skin, and it is probable that the antifungal, antiviral, and antibacterial properties of these quinones are the result of redox cycling.
Journal ArticleDOI
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.
L Salmon-Chemin,E Buisine,Yardley,S Kohler,MA Debreu,Landry,C Sergheraert,Simon L. Croft,RL Krauth-Siegel,Elisabeth Davioud-Charvet +9 more
TL;DR: The results obtained here confirm that reduction of NQs by parasitic flavoenzymes is a promising strategy for the development of new trypanocidal drugs.
Journal ArticleDOI
Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L.
TL;DR: It was found that the walnut pellicle is the most important source of walnut phenolics, and the ratio between the contents in pellicles and kernel varied by at least 14.8-fold.