One Juliet and four Romeos: VeA and its methyltransferases.
TLDR
Interaction of VeA with at least four methyltransferase proteins indicates a molecular hub function for VeA that questions: Is there a VeA supercomplex or is VeA part of a highly dynamic cellular control network with many different partners?Abstract:
Fungal secondary metabolism has become an important research topic with great biomedical and biotechnological value. In the postgenomic era, understanding the diversity and the molecular control of secondary metabolites are two challenging tasks addressed by the research community. Discovery of the LaeA methyltransferase 10 years ago opened up a new horizon on the control of secondary metabolite research when it was found that expression of many secondary metabolite gene clusters is controlled by LaeA. While the molecular function of LaeA remains an enigma, discovery of the velvet family proteins as interaction partners further extended the role of the LaeA beyond secondary metabolism. The heterotrimeric VelB-VeA-LaeA complex plays important roles in development, sporulation, secondary metabolism and pathogenicity. Recently, three other methyltransferases have been found to associate with the velvet complex, the LaeA-like methyltransferase F (LlmF) and the methyltransferase heterodimers VipC-VapB. Interaction of VeA with at least four methyltransferase proteins indicates a molecular hub function for VeA that questions: Is there a VeA supercomplex or is VeA part of a highly dynamic cellular control network with many different partners?read more
Citations
More filters
Journal ArticleDOI
Efficient techniques for the removal of toxic heavy metals from aquatic environment: A review
TL;DR: In this article, the authors provide a sketch about treatment technologies followed by their heavy metal capture capacity from industrial effluent, the treatment performance, their remediation capacity and probable environmental and health impacts were deliberated in this review article.
Journal ArticleDOI
Bioremediation techniques–classification based on site of application: principles, advantages, limitations and prospects
TL;DR: The two major approaches to enhance bioremediation are biostimulation and bioaugmentation provided that environmental factors, which determine the success of biOREmediation, are maintained at optimal range.
Journal ArticleDOI
Trade-offs between multifunctionality and profit in tropical smallholder landscapes
Ingo Grass,Ingo Grass,Christoph Kubitza,Christoph Kubitza,Vijesh V. Krishna,Marife D. Corre,Oliver Mußhoff,Peter Pütz,Jochen Drescher,Katja Rembold,Katja Rembold,Eka Sulpin Ariyanti,Andrew D. Barnes,Nicole Brinkmann,Ulrich Brose,Bernhard Brümmer,Damayanti Buchori,Rolf Daniel,Kevin Darras,Heiko Faust,Lutz Fehrmann,Jonas Hein,Nina Hennings,Purnama Hidayat,Dirk Hölscher,Malte Jochum,Malte Jochum,Alexander Knohl,Martyna M. Kotowska,Valentyna Krashevska,Holger Kreft,Christoph Leuschner,Neil Jun S. Lobite,Rawati Panjaitan,Andrea Polle,Anton M. Potapov,Anton M. Potapov,Edwine Setia Purnama,Matin Qaim,Alexander Röll,Stefan Scheu,Dominik Schneider,Aiyen Tjoa,Teja Tscharntke,Edzo Veldkamp,Meike Wollni +45 more
TL;DR: Landscape compositions that can mitigate trade-offs under optimal land-use allocation but also show that intensive monocultures always lead to higher profits are identified, suggesting that targeted landscape planning is needed to increase land- use efficiency while ensuring socio-ecological sustainability.
Journal ArticleDOI
Revitalization of plant growth promoting rhizobacteria for sustainable development in agriculture.
Sushanto Gouda,Rout George Kerry,Gitishree Das,Spiros Paramithiotis,Han-Seung Shin,Jayanta Kumar Patra +5 more
TL;DR: Plant growth promoting rhizobacteria (PGPR) has been functioning as a co-evolution between plants and microbes showing antagonistic and synergistic interactions with microorganisms and the soil.
VelB/VeA/LaeA Complex CoordinatesLight Signal with Fungal Developmentand Secondary Metabolism
Özgür Bayram,Sven Krappmann,Min Ni,Jin Woo Bok,Kerstin Helmstaedt,Oliver Valerius,Susanna A. Braus-Stromeyer,Nak-Jung Kwon,Nancy P. Keller,Jae-Hyuk Yu,Gerhard H. Braus +10 more
TL;DR: This work has identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism in Aspergillus nidulans, which inhibits sexual reproduction as well as secondary metabolism.
References
More filters
Journal ArticleDOI
The Fungi: 1, 2, 3 … 5.1 million species?
TL;DR: Technological advances make it possible to apply molecular methods to develop a stable classification and to discover and identify fungal taxa, revealing a monophyletic kingdom and increased diversity among early-diverging lineages.
Journal ArticleDOI
Fungal Community Analysis by Large-Scale Sequencing of Environmental Samples
TL;DR: The high rate at which new sequence types were recovered even after sampling 863 fungal ITS sequences and the dominance of fungi in the authors' libraries relative to other eukaryotes suggest that the abundance and diversity of fungiIn forest soils may be much higher than previously hypothesized.
Journal ArticleDOI
Regulation of fungal secondary metabolism
TL;DR: This Review describes the current understanding of the regulatory elements that modulate the transcription of genes involved in secondary metabolism and discusses how an improved knowledge of these regulatory elements will ultimately lead to a betterUnderstanding of the physiological and ecological functions of these important compounds.
Journal ArticleDOI
LaeA, a Regulator of Secondary Metabolism in Aspergillus spp.
Jin Woo Bok,Nancy P. Keller +1 more
TL;DR: A novel Aspergillus nuclear protein, LaeA, is presented here as a global regulator of secondary metabolism in this genus, and strains show little difference in spore production compared to the wild type, indicating that the primary role of laeA is to regulate metabolic gene clusters.
Journal ArticleDOI
VelB/VeA/LaeA Complex Coordinates Light Signal with Fungal Development and Secondary Metabolism
Özgür Bayram,Sven Krappmann,Min Ni,Jin Woo Bok,Kerstin Helmstaedt,Kerstin Helmstaedt,Oliver Valerius,Susanna A. Braus-Stromeyer,Nak-Jung Kwon,Nancy P. Keller,Jae-Hyuk Yu,Gerhard H. Braus +11 more
TL;DR: In this article, the authors identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism in Aspergillus nidulans.
Related Papers (5)
QIIME allows analysis of high-throughput community sequencing data.
J. Gregory Caporaso,Justin Kuczynski,Jesse Stombaugh,Kyle Bittinger,Frederic D. Bushman,Elizabeth K. Costello,Noah Fierer,Antonio Gonzalez Peña,Julia K. Goodrich,Jeffrey I. Gordon,Gavin A. Huttley,Scott T. Kelley,Dan Knights,Jeremy E. Koenig,Ruth E. Ley,Catherine A. Lozupone,Daniel McDonald,Brian D. Muegge,Meg Pirrung,Jens Reeder,Joel Sevinsky,Peter J. Turnbaugh,William A. Walters,Jeremy Widmann,Tanya Yatsunenko,Jesse R. Zaneveld,Rob Knight,Rob Knight +27 more
Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities
Patrick D. Schloss,Patrick D. Schloss,Sarah L. Westcott,Sarah L. Westcott,Thomas Ryabin,Justine R. Hall,Martin Hartmann,Emily B. Hollister,Ryan A. Lesniewski,Brian B. Oakley,Donovan H. Parks,Courtney J. Robinson,Jason W. Sahl,Blaz Stres,Gerhard G. Thallinger,David J. Van Horn,Carolyn F. Weber +16 more