Journal ArticleDOI
Pharmacological uses and perspectives of heavy water and deuterated compounds
TLDR
D2O and deuterated drugs are widely used in studies of metabolism of drugs and toxic substances in humans and other animals, and most are more resistant to metabolic changes, especially those changes mediated by cytochrome P450 systems.Abstract:
Since the discovery of D2O (heavy water) and its use as a moderator in nuclear reactors, its biological effects have been extensively, although seldom deeply, studied. This article reviews these ef...read more
Citations
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Journal ArticleDOI
Singlet oxygen: there is indeed something new under the sun
TL;DR: In this critical review, recent work on singlet oxygen is summarized, focusing primarily on systems that involve light.
Journal ArticleDOI
Production and characterization of clinical grade exosomes derived from dendritic cells.
Henry Lamparski,Anita Metha-Damani,Jenq-Yuan Yao,Sanjay Patel,Di-Hwei Hsu,Curtis L. Ruegg,Jean-Bernard Le Pecq +6 more
TL;DR: The combination of a rapid and reproducible purification method and quality control assays for exosomes has allowed for its evaluation as a cancer vaccine in clinical trials and the following quality control Assays to standardize the exosome vaccine are developed.
Journal ArticleDOI
Sites and Regulation of Auxin Biosynthesis in Arabidopsis Roots
Karin Ljung,Anna K. Hull,John L. Celenza,Masashi Yamada,Mark Estelle,Jennifer Normanly,Göran Sandberg +6 more
TL;DR: A model is presented for how the primary root is supplied with auxin during early seedling development and lower but significant synthesis capacity was observed in tissues upward from the tip, showing that the root contains multiple auxin sources.
Journal ArticleDOI
Using Deuterium in Drug Discovery: Leaving the Label in the Drug
TL;DR: This Perspective traces the author's experience in reviving and expanding this potential utility of deuterium, first suggested many decades prior by the discoverer of this, the simplest of all isotopes.
Journal ArticleDOI
Nuclear Quantum Effects in Water and Aqueous Systems: Experiment, Theory, and Current Challenges
Michele Ceriotti,Wei Fang,Peter G. Kusalik,Ross H. McKenzie,Angelos Michaelides,Miguel A. Morales,Thomas E. Markland +6 more
TL;DR: The latest major developments in simulation algorithms and theory that have enabled the efficient inclusion of nuclear quantum effects in molecular simulations, permitting their combination with on-the-fly evaluation of the potential energy surface using electronic structure theory are reviewed.
References
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Book
The Structure and Properties of Water
David Eisenberg,Walter Kauzmann +1 more
TL;DR: The Water Molecule 2 The Real Vapour 3. Ice 4. Properties of Liquid Water 5. Models for Liquid Water Addendum as mentioned in this paper, which is an extension of the model presented in this paper.
Book
Nuclear Chemical Engineering
TL;DR: The branch of chemical engineering that deals with the production and use of radioisotopes, nuclear energy, and nuclear power is a branch of the Chemical Engineering Department of MIT.