Plants as a source of anti-cancer agents.
Gordon M. Cragg,David J. Newman +1 more
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TLDR
A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest.About:
This article is published in Journal of Ethnopharmacology.The article was published on 2005-08-22 and is currently open access. It has received 1794 citations till now. The article focuses on the topics: Epipodophyllotoxin & Camptothecin.read more
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Flavonoids and Other Phenolic Compounds from Medicinal Plants for Pharmaceutical and Medical Aspects: An Overview.
TL;DR: This review attempts to demonstrate an overview of flavonoids and other phenolic compounds as the interesting alternative sources for pharmaceutical and medicinal applications.
Journal ArticleDOI
Natural products as leads to anticancer drugs.
TL;DR: Semisynthesis processes of new compounds, obtained by molecular modification of the functional groups of lead compounds, are able to generate structural analogues with greater pharmacological activity and with fewer side effects.
Journal ArticleDOI
Natural products for cancer chemotherapy
Arnold L. Demain,Preeti Vaishnav +1 more
TL;DR: This review points out those technologies needed to produce the anti‐tumour compounds of the future, with fewer side‐effects and/or with greater therapeutic efficiency.
Journal IssueDOI
Medicinal Plants: Their Use in Anticancer Treatment.
TL;DR: The demand for naturally-derived compounds from medicinal plants and their properties which make them targets for potential anticancer treatments are discussed.
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Anticancer compounds derived from fungal endophytes: their importance and future challenges.
TL;DR: This is a review of anticancer agents isolated from endophytic fungi from 1990–2010, based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines.
References
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Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
Journal ArticleDOI
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
TL;DR: It is shown that cyclopamine can reverse the retention of partially misfolded Smo in the endoplasmic reticulum through binding-mediated effects on protein conformation, which suggests a role for small molecules in the physiological regulation of Smo.
Reference BookDOI
Anticancer Agents from Natural Products
TL;DR: This work focuses on the discovery and development of novel Antitumor Agents from Dolabella auricularia, as well as the evaluation of (+)-CC-1065 Analogs and Conjugates with Polyamides and their applications in Anticancer Natural Products.
Journal ArticleDOI
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
TL;DR: Because of its selective cytotoxicity against tumor cells and favorable therapeutic index, even at doses up to 500 mg/kg body weight, betulinic acid is a very promising new chemotherapeutic agent for the treatment of HIV infection and cancer.
Related Papers (5)
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more