Journal ArticleDOI
Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications
TLDR
A State-of-the-art use of PEG in therapeutic applications, its clinical status and commercial use is summarized, and toxicities related to different PEG grades and related impurities are discussed in this review.Abstract:
Introduction: Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile: prime requisites considered during the selection of any excipient in formulation development.Areas covered: The unique properties and applications of PEG have been discussed at length in the existing literature. However, a proper guidance on selection of PEG grade to cater to one’s purpose is lacking. This article provides preliminary guidelines to formulators on selection of appropriate PEG grade, typically based on its physico-chemical properties and role-based functional application in pharmaceuticals. It should be noted that the aim article is not to deep dive in each application area.Expert opinion: Guidance on PEG application and grade of choice is lacking in the available literature. The authors have discussed and provided guidance to formulators on the appropriate PEG grade selection for particular...read more
Citations
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3D printing of hydrogels: Rational design strategies and emerging biomedical applications
TL;DR: A review of hydrogel-based biomaterial inks and bioinks for 3D printing can be found in this paper, where the authors provide a comprehensive overview and discussion of the tailorability of material, mechanical, physical, chemical and biological properties.
Journal ArticleDOI
The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation.
Thai Thanh Hoang Thi,Emily H. Pilkington,Dai Hai Nguyen,Jung Seok Lee,Ki Dong Park,Nghia P. Truong +5 more
TL;DR: Recent literature is collated to draw the attention of polymer chemists to the issue of PEG immunogenicity in drug delivery and bioconjugation, thereby highlighting the importance of developing alternative polymers to replace PEG.
Journal ArticleDOI
Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics
TL;DR: This mini-review presents a toolbox of modifications in peptide chemistry for overcoming the main drawbacks during the transition from natural peptides to peptide therapeutics.
Journal ArticleDOI
Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery
Liwang Shi,Jinqiu Zhang,Man Zhao,Shukun Tang,Xu Cheng,Wenyuan Zhang,Wenhua Li,Xiaoying Liu,Haisheng Peng,Qun Wang +9 more
TL;DR: In this article, the authors discuss the PEGylation methods of nanoparticles and related techniques that have been used to detect the coverage density and thickness on the surface of the nanoparticles in recent years.
Journal ArticleDOI
Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing.
TL;DR: In this review, after shedding light on hemostasis and wound healing processes, the most recent progresses in hydrogel systems engineered from natural and synthetic polymers for hemostatic applications are discussed based on a comprehensive literature review.
References
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Mussel-Inspired Surface Chemistry for Multifunctional Coatings
TL;DR: Inspired by the composition of adhesive proteins in mussels, dopamine self-polymerization is used to form thin, surface-adherent polydopamine films onto a wide range of inorganic and organic materials, including noble metals, oxides, polymers, semiconductors, and ceramics.
Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Effect of pegylation on pharmaceuticals
J. Milton Harris,Robert B. Chess +1 more
TL;DR: How PEGylation can result in drugs that are often more effective and safer, and which show improved patient convenience and compliance are reviewed.
Journal ArticleDOI
Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives
TL;DR: PEG is the most used polymer and also the gold standard for stealth polymers in the emerging field of polymer-based drug delivery and alternative polymers will be evaluated.
Journal ArticleDOI
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
TL;DR: The PEG‐PE's activity to prolong the circulation time of liposomes is greater than that of the ganglioside GM1, awell‐described glycolipid with this activity.