Polymeric scaffolds in tissue engineering application: a review
TLDR
An overview of the different types of scaffolds with their material properties is discussed and the fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.Abstract:
Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.read more
Citations
More filters
Journal ArticleDOI
An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering
TL;DR: The analysis of the state of the art in the field reveals the presence of current innovative techniques for scaffolds and material manufacturing that are currently opening the way to prepare biomimetic PLGA substrates able to modulate cell interaction for improved substitution, restoration, or enhancement of bone tissue function.
Journal ArticleDOI
Scaffolds for Bone Tissue Engineering: State of the art and new perspectives.
Livia Roseti,V. Parisi,Mauro Petretta,Carola Cavallo,Giovanna Desando,Isabella Bartolotti,Brunella Grigolo +6 more
TL;DR: It is highlighted that, despite its encouraging results, the clinical approach of Bone Tissue Engineering has not taken place on a large scale yet, due to the need of more in depth studies, its high manufacturing costs and the difficulty to obtain regulatory approval.
Journal ArticleDOI
Bone regenerative medicine: classic options, novel strategies, and future directions
TL;DR: Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.
Journal ArticleDOI
Industrial applications of crustacean by-products (chitin, chitosan, and chitooligosaccharides): A review
TL;DR: In this paper, a review summarizes the current state of knowledge of these crustacean shellfish shellfish wastes and the various ways to use chitin, a polysaccharide that may be extracted after deproteinisation and demineralization of the exoskeletons.
Journal ArticleDOI
Is It Time to Start Transitioning From 2D to 3D Cell Culture
Caleb Jensen,Yong Teng +1 more
TL;DR: 3D cellculture has the potential to provide alternative ways to study organ behavior via the use of organoids and is expected to eventually bridge the gap between 2D cell culture and animal models.
References
More filters
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal ArticleDOI
Biodegradable polymers as biomaterials
TL;DR: This review summarizes the main advances published over the last 15 years, outlining the synthesis, biodegradability and biomedical applications ofBiodegradable synthetic and natural polymers.
Journal ArticleDOI
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.