Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors
TLDR
Specific barriers to medication adherence in T2D, especially those that are potentially modifiable, need to be more clearly identified and strategies that target poor adherence should focus on reducing medication burden and addressing negative medication beliefs of patients.Abstract:
At least 45% of patients with type 2 diabetes (T2D) fail to achieve adequate glycemic control (HbA1c <7%). One of the major contributing factors is poor medication adherence. Poor medication adherence in T2D is well documented to be very common and is associated with inadequate glycemic control; increased morbidity and mortality; and increased costs of outpatient care, emergency room visits, hospitalization, and managing complications of diabetes. Poor medication adherence is linked to key nonpatient factors (eg, lack of integrated care in many health care systems and clinical inertia among health care professionals), patient demographic factors (eg, young age, low education level, and low income level), critical patient beliefs about their medications (eg, perceived treatment inefficacy), and perceived patient burden regarding obtaining and taking their medications (eg, treatment complexity, out-of-pocket costs, and hypoglycemia). Specific barriers to medication adherence in T2D, especially those that are potentially modifiable, need to be more clearly identified; strategies that target poor adherence should focus on reducing medication burden and addressing negative medication beliefs of patients. Solutions to these problems would require behavioral innovations as well as new methods and modes of drug delivery.read more
Citations
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Impact of mobile phone text messaging intervention on adherence among patients with diabetes in a rural setting: A randomized controlled trial.
TL;DR: The text messaging intervention did not bring about any significant improvement in medication, dietary and physical activity adherence levels, and there is a need to design effective strategies for improving adherence to recommended lifestyle changes in this setting.
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Reproducibility and Validity of a Questionnaire Measuring Treatment Burden on Patients with Type 2 Diabetes: Diabetic Treatment Burden Questionnaire (DTBQ).
Hitoshi Ishii,Koki Shin,Takahiro Tosaki,Tatsuya Haga,Yoshiki Nakajima,Toshihiko Shiraiwa,Nobuaki Watanabe,Miyuki Koizumi,Hiroki Nakajima,Sadanori Okada,Tsuyoshi Mashitani,Takako Mohri,Yasuhiro Akai +12 more
TL;DR: The DTBQ has adequate reproducibility and validity as a measurement scale for treatment burden on T2DM patients and as the dosing frequency of diabetic medicines increased, the D TBQ total score (total burden score) also became higher.
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Vanadium(IV)-diamine complex with hypoglycemic activity and a reduction in testicular atrophy.
Lidiane Macedo Alves de Lima,Mônica F. Belian,Wagner Eduardo Da Silva,Kahoana Postal,Kateryna Kostenkova,Debbie C. Crans,Ana Katharyne Ferreira Fagundes Rossiter,Valdemiro Amaro da Silva Junior +7 more
TL;DR: These studies demonstrate that the VIVO(BHED) complex or its decomposition products show similar effects as insulin in decreasing elevated blood glucose levels.
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Regimen simplification and medication adherence: Fixed-dose versus loose-dose combination therapy for type 2 diabetes
TL;DR: In this paper, the effects of fixed-dose combination versus loosedose combination therapy on medication adherence and persistence, health care utilization, therapeutic safety, morbidities, and treatment modification in patients with type 2 diabetes over three years were compared.
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Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT)
Wilma S Leslie,Eman Ali,Leanne Harris,C. Martina Messow,Naomi Brosnahan,George Thom,E Louise McCombie,Alison C. Barnes,Naveed Sattar,Roy Taylor,Michael E. J. Lean +10 more
TL;DR: In this paper, the authors evaluated the safety and efficacy of a planned therapeutic withdrawal of all antihypertensive and diuretic medications, on commencing a formula low-energy diet replacement, targeting remission of type 2 diabetes.
References
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Journal ArticleDOI
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Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient- Centered Approach
Journal ArticleDOI
Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus.
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TL;DR: Medication nonadherence is prevalent among patients with diabetes mellitus and is associated with adverse outcomes, and interventions are needed to increase medication adherence so that patients can realize the full benefit of prescribed therapies.