Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery.
Tarek A. Ahmed,Bader M Aljaeid +1 more
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TLDR
Therapeutic agent-loaded chitosan micro- or nanoparticles were found to be more stable, permeable, and bioactive, while reviewing the pharmaceutical applications of these particles in drug delivery.Abstract:
Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the second abundant naturally occurring polysaccharide next to cellulose, is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of micro-as well as nanoparticles. The prepared particles have been exploited as a potential carrier for different therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and nonparenteral administration. Therapeutic agent-loaded chitosan micro- or nanoparticles were found to be more stable, permeable, and bioactive. In this review, we are highlighting the different methods of preparation and characterization of chitosan micro- and nanoparticles, while reviewing the pharmaceutical applications of these particles in drug delivery. Moreover, the roles of chitosan derivatives and chitosan metal nanoparticles in drug delivery have been illustrated.read more
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An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery
TL;DR: Chitosan-based NP have various applications in non-parenteral drug delivery for the treatment of cancer, gastrointestinal diseases, pulmonary diseases, drug delivery to the brain and ocular infections which will be exemplified in this review.
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Preparation and Characterization of Chitosan Obtained from Shells of Shrimp (Litopenaeus vannamei Boone)
Rayane Santa Cruz Martins de Queiroz Antonino,Bianca Rosa Paschoal Lia Fook,Vítor Alexandre de Oliveira Lima,Raid Ícaro de Farias Rached,Eunice Paloma Nascimento Lima,Rodrigo José Da Silva Lima,Carlos Peniche Covas,Marcus Vinícius Lia Fook +7 more
TL;DR: It is concluded that the procedure developed in the present work allowed obtaining chitosans with physical and chemical properties suitable for pharmaceutical applications.
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Electrophoretic deposition of chitosan-based composite coatings for biomedical applications: A review
Egemen Avcu,Egemen Avcu,Egemen Avcu,Fatih Erdem Bastan,Fatih Erdem Bastan,Hasan Zuhudi Abdullah,Hasan Zuhudi Abdullah,Muhammad Atiq Ur Rehman,Muhammad Atiq Ur Rehman,Yasemin Yıldıran Avcu,Yasemin Yıldıran Avcu,Aldo R. Boccaccini +11 more
TL;DR: A comprehensive review of the field of electrophoretic deposition of chitosan-based composite coatings by highlighting their microstructural, mechanical, surface, and biological properties is presented in this paper.
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Nanotechnology: An Untapped Resource for Food Packaging.
TL;DR: The existing knowledge, recent advances, concerns and future applications of nanotechnology in food packaging sector are presented.
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Chitosan-based (Nano)materials for Novel Biomedical Applications.
TL;DR: Chitosan is presented as an ideal biomaterial for antimicrobial wound dressings that can either be fabricated alone in its native form or upgraded and incorporated with antibiotics, metallic antimicrobial particles, natural compounds and extracts in order to increase the antimicrobial effect.
References
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Journal ArticleDOI
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Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
Journal ArticleDOI
Chitosan—A versatile semi-synthetic polymer in biomedical applications
TL;DR: The chemical structure and relevant biological properties of chitosan for regenerative medicine have been summarized as well as the methods for the preparation of controlled drug release devices and their applications.
Book
Pharmaceutics : the science of dosage form design
TL;DR: The design of dosage forms, principles of sterilization practice, and the operation of clean rooms are described, which will help clarify the role of bioavailability in drug delivery.
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