Journal ArticleDOI
Primary and secondary mechanisms of action of visible to near-IR radiation on cells.
TLDR
A cascade of reactions connected with alteration in cellular homeostasis parameters (pHi, [Cai], cAMP, Eh, [ATP] and some others) is considered as a photosignal transduction and amplification chain in a cell (secondary mechanisms).Abstract:
Cytochrome c oxidase is discussed as a possible photoacceptor when cells are irradiated with monochromatic red to near-IR radiation. Four primary action mechanisms are reviewed: changes in the redox properties of the respiratory chain components following photoexcitation of their electronic states, generation of singlet oxygen, localized transient heating of absorbing chromophores, and increased superoxide anion production with subsequent increase in concentration of the product of its dismutation, H2O2. A cascade of reactions connected with alteration in cellular homeostasis parameters (pHi, [Cai], cAMP, Eh, [ATP] and some others) is considered as a photosignal transduction and amplification chain in a cell (secondary mechanisms).read more
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Journal ArticleDOI
The Nuts and Bolts of Low-level Laser (Light) Therapy
Hoon Chung,Tianhong Dai,Sulbha K. Sharma,Ying-Ying Huang,Ying-Ying Huang,James D. Carroll,Michael R. Hamblin,Michael R. Hamblin +7 more
TL;DR: The mechanisms of action of LLLT at a cellular and at a tissular level are covered and the various light sources and principles of dosimetry that are employed in clinical practice are summarized.
Journal ArticleDOI
Biphasic Dose Response in Low Level Light Therapy
TL;DR: The molecular and cellular mechanisms in LLLT are covered, and some of the recent results in vitro and in vivo that provide scientific explanations for this biphasic dose response are described.
Journal ArticleDOI
Mitochondrial dysfunction as a cause of optic neuropathies
TL;DR: The recent identification of mutations in the nuclear gene OPA1 as the causative factor in dominant optic atrophy (DOA) brought the unexpected finding that this gene encodes for a mitochondrial protein, suggesting that DOA and LHON may be linked by similar pathogenesis.
Journal ArticleDOI
Bioinorganic photochemistry: frontiers and mechanisms.
Konrad Szaciłowski,Wojciech Macyk,Agnieszka Drzewiecka-Matuszek,Małgorzata Brindell,Grazyna Stochel +4 more
Journal ArticleDOI
Biphasic dose response in low level light therapy – an update
TL;DR: Transcranial LLLT for traumatic brain injury in mice shows a distinct biphasic pattern with peaks in beneficial neurological effects observed when the number of treatments is varied, and when the energy density of an individual treatment is varied.
References
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Journal ArticleDOI
Electron transfers in chemistry and biology
Rudolph A. Marcus,Norman Sutin +1 more
TL;DR: In this paper, the electron transfer reactions between ions and molecules in solution have been the subject of considerable experimental study during the past three decades, including charge transfer, photoelectric emission spectra, chemiluminescent electron transfer, and electron transfer through frozen media.
Journal ArticleDOI
Oxidative stress as a mediator of apoptosis
Thomas M. Buttke,Paul Sandstrom +1 more
TL;DR: Thomas Buttke and Paul Sandstrom suggest that eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis.
Journal ArticleDOI
The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A.
Tomitake Tsukihara,Hiroshi Aoyama,Eiki Yamashita,Takashi Tomizaki,Hiroshi Yamaguchi,Kyoko Shinzawa-Itoh,Ryosuke Nakashima,Rieko Yaono,Shinya Yoshikawa +8 more
TL;DR: Two possible proton pathways for pumping, each spanning from the matrix to the cytosolic surfaces, were identified, including hydrogen bonds, internal cavities likely to contain water molecules, and structures that could form hydrogen bonds with small possible conformational change of amino acid side chains.