Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
TLDR
An overview of the host response and how the genomic capacity of P. aeruginosa contributes to the pathogenesis and persistence of these infections is provided.Abstract:
Pseudomonas aeruginosa is a metabolically versatile bacterium that can cause a wide range of severe opportunistic infections in patients with serious underlying medical conditions. These infections are characterized by an intense neutrophilic response resulting in significant damage to host tissues and often exhibit resistance to antibiotics leading to mortality. Treatment of persistent infections is additionally hampered by adaptive resistance, due to the growth state of the bacterium in the patient including the microorganism's ability to grow as a biofilm. An array of P. aeruginosa virulence factors counteract host defences and can cause direct damage to host tissues or increase the bacterium's competitiveness. New prevention and treatment methods are urgently required to improve the outcome of patients with P. aeruginosa infections. This review describes the two main types of P. aeruginosa lung infections and provides an overview of the host response and how the genomic capacity of P. aeruginosa contributes to the pathogenesis and persistence of these infections.read more
Citations
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Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
TL;DR: The mechanism of antibiotic resistance in P. aeruginosa is a recently characterized mechanism, which includes biofilm-mediated resistance and formation of multidrug-tolerant persister cells, and is responsible for recalcitrance and relapse of infections.
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Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence.
TL;DR: The central regulatory role of quorum sensing and signaling systems by nucleotide-based second messengers resulting in different lifestyles of P. aeruginosa is reviewed and various regulatory proteins will be discussed which form a plethora of controlling systems acting at transcriptional level for timely expression of genes enabling rapid responses to external stimuli and unfavorable conditions.
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Antimicrobial resistance in ESKAPE pathogens
David M. P. De Oliveira,Brian M. Forde,Timothy J. Kidd,Patrick N A Harris,Mark A. Schembri,Scott A. Beatson,David L. Paterson,Mark J. Walker +7 more
TL;DR: The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antim antibiotic resistance surveillance.
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The increasing threat of Pseudomonas aeruginosa high-risk clones.
TL;DR: The population structure, epidemiology, antimicrobial resistance mechanisms and virulence of the P. aeruginosa high-risk clones are reviewed and the aspects related to their detection in the clinical microbiology laboratory and the implications for infection control and public health are discussed.
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Blood Groups in Infection and Host Susceptibility
TL;DR: Several distinct phenotypes associated with increased host resistance to malaria are overrepresented in populations living in areas where malaria is endemic, as a result of evolutionary pressures.
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
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