Quality of life of people living with HIV and AIDS and antiretroviral therapy
TLDR
The development of antiretroviral drugs has significantly changed the perception of HIV/AIDS from a very fatal to a chronic and potentially manageable disease, and the availability and administration of ART has significantly reduced mortality and morbidity associated with HIV and AIDS.Abstract:
The development of antiretroviral drugs has significantly changed the perception of HIV/AIDS from a very fatal to a chronic and potentially manageable disease, and the availability and administration of antiretroviral therapy (ART) has significantly reduced mortality and morbidity associated with HIV and AIDS. There is a relationship between ART and quality of life of people living with HIV and AIDS, and several studies have reported a strong positive association between ART and improved quality of life in different domains among people living with HIV and AIDS in both developed and developing countries. However, a few studies have reported on the negative effects of ART, which directly or indirectly relate to the quality of life and longevity of HIV-infected persons. In this review, the effects and benefits of ART on people living with HIV and AIDS based on studies done in developed and developing countries is examined.read more
Citations
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Cardiovascular risk and dyslipidemia among persons living with HIV: a review
Paolo Maggi,Antonio Di Biagio,Stefano Rusconi,Stefania Cicalini,Maurizio D’Abbraccio,Gabriella d'Ettorre,Canio Martinelli,Giuseppe Nunnari,Laura Sighinolfi,Vincenzo Spagnuolo,Nicola Squillace +10 more
TL;DR: Cardiovascular risk among HIV infected patients, interventions on behavior and lifestyles, use of drugs to reduce the risk, and switch in antiretroviral therapy, remain nowadays major issues in the management of HIV-infected patients.
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Improved quality of life with immediate versus deferred initiation of antiretroviral therapy in early asymptomatic HIV infection
Alan R. Lifson,Birgit Grund,Edward M. Gardner,Richard Kaplan,Eileen Denning,Nicole Engen,Catherine L. Carey,Fabian Chen,Sounkalo Dao,Eric Florence,Jesús Sanz,Sean Emery +11 more
TL;DR: There were modest but significant improvements in self-assessed QOL among those initiating ART immediately compared to deferring treatment, supporting patient-perceived health benefits of initiating ART as soon as possible after an HIV diagnosis.
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Cohort profile: The Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS)
Mona Loutfy,Mona Loutfy,Alexandra de Pokomandy,Alexandra de Pokomandy,V. Logan Kennedy,Allison Carter,Allison Carter,Nadia O’Brien,Karène Proulx-Boucher,Erin Ding,Johanna Lewis,Johanna Lewis,Valerie Nicholson,Kerrigan Beaver,Saara Greene,Wangari Tharao,Anita C Benoit,Anita C Benoit,Danièle Dubuc,Jamie Thomas-Pavanel,Jamie Thomas-Pavanel,Paul Sereda,Shahab Jabbari,Jayson H. Shurgold,Guillaume Colley,Robert S. Hogg,Robert S. Hogg,Angela Kaida +27 more
TL;DR: The Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS) is developed to investigate the concept of women-centred HIV care (WCHC) and its impact on the overall, HIV, women’s, mental, sexual, and reproductive health outcomes of women living with HIV.
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Effects of Combined Aerobic and Resistance Exercise on Exercise Capacity, Muscle Strength and Quality of Life in HIV-Infected Patients: A Systematic Review and Meta-Analysis.
TL;DR: Combined aerobic and resistance exercise may improve peak VO2, muscle strength and health status, energy and physical function domains of quality of life and should be considered as a component of care of HIV-infected individuals.
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Comparison of Treatment Outcomes of New Smear-Positive Pulmonary Tuberculosis Patients by HIV and Antiretroviral Status in a TB/HIV Clinic, Malawi
Hannock Tweya,Caryl Feldacker,Sam Phiri,Anne Ben-Smith,Lukas Fenner,Andreas Jahn,Mike Kalulu,Ralf Weigel,Chancy Kamba,Rabecca Banda,Matthias Egger,Olivia Keiser +11 more
TL;DR: Intensified patient education and provider training could increase antiretroviral therapy uptake and improve TB treatment success among these most infectious patients.
References
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Journal ArticleDOI
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Journal ArticleDOI
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David L. Paterson,Susan Swindells,J. Mohr,Michelle Brester,Emanuel N. Vergis,Cheryl Squier,Marilyn M. Wagener,Nina Singh +7 more
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Journal ArticleDOI
Combination antiretroviral therapy and the risk of myocardial infarction
Nina Friis-Møller,Caroline A. Sabin,Rainer Weber,Antonella d'Arminio Monforte,Wafaa El-Sadr,Peter Reiss,Rodolphe Thiébaut,Linda Morfeldt,Stéphane De Wit,Christian Pradier,Gonzalo Calvo,Matthew Law,Ole Kirk,Andrew N. Phillips,Jens D Lundgren +14 more
TL;DR: Combination antiretroviral therapy was independently associated with a 26 percent relative increase in the rate of myocardial infarction per year of exposure during the first four to six years of use, however, the absolute risk of my Cardiac Infarction was low and must be balanced against the marked benefits from antireTroviral treatment.
Journal ArticleDOI
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
John D. Hayes,Lesley I. McLellan +1 more
TL;DR: Howglutathione biosynthesis, glutathione peroxidases, glutATHione S-transferases and glutathion S-conjugate efflux pumps function in an integrated fashion to allow cellular adaption to oxidative stress is discussed.
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Rates of Disease Progression by Baseline CD4 Cell Count and Viral Load After Initiating Triple-Drug Therapy
Robert S. Hogg,Benita Yip,Keith Chan,Evan Wood,Kevin J. P. Craib,Michael V. O'Shaughnessy,Julio S. G. Montaner +6 more
TL;DR: The data demonstrate uniformly low rates of disease progression to death and AIDS or death among patients starting antiretroviral therapy with CD4 cell counts of at least 200/microL, as well as a prior diagnosis of acquired immunodeficiency syndrome (AIDS).