Reduction in surface contamination with antineoplastic drugs in 22 hospital pharmacies in the US following implementation of a closed-system drug transfer device
TLDR
Use of the CSTD significantly reduces surface contamination when preparing cyclophosphamide, ifosfamide, and 5-fluorouracil as compared to standard drug preparation techniques.Abstract:
Purpose
Surface contamination with the antineoplastic drugs cyclophosphamide, ifosfamide, and 5-fluorouracil was compared in 22 US hospital pharmacies following preparation with standard drug preparation techniques or the PhaSeal® closed-system drug transfer device (CSTD).read more
Citations
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Journal ArticleDOI
Reproductive Health Risks Associated with Occupational Exposures to Antineoplastic Drugs in Health Care Settings: A Review of the Evidence
TL;DR: Occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage and health care workers with long-term, low-level occupational exposure to these drugs also seem to have an increased risk of adverse reproductive outcomes.
Journal ArticleDOI
Occupational exposure to antineoplastic drugs in four Italian health care settings.
TL;DR: R residue contamination on surfaces and floors has continued to be assessed in all the investigated sites and despite the adherence to the recommended safety practices residue contamination in pharmacies was generally more contaminated than patient areas.
Journal ArticleDOI
Reduction in Surface Contamination With Cyclophosphamide in 30 US Hospital Pharmacies Following Implementation of a Closed-System Drug Transfer Device
TL;DR: The CSTD significantly reduced, but did not totally eliminate, surface contamination with cyclophosphamide, and increased usage of CSTDs should be employed to help protect health care workers from exposure to hazardous drugs.
Journal ArticleDOI
Surface wipe sampling for antineoplastic (chemotherapy) and other hazardous drug residue in healthcare settings: Methodology and recommendations
TL;DR: The purpose of this article is to review published studies of wipe sampling for antineoplastic and other hazardous drugs, to summarize the methods in use by various organizations and researchers, and to provide some basic guidance for conducting surface wiped sampling for these drugs in healthcare settings.
Journal ArticleDOI
Safe handling of cytotoxics: guideline recommendations
Anthony C. Easty,N. Coakley,R. Cheng,M. Cividino,Pamela Savage,Richard Tozer,Rachel E. White +6 more
TL;DR: Reducing the likelihood of accidental exposure to cytotoxic agents within the medication circuit is the main objective of this evidenced-based guideline, which differs slightly from earlier guidelines because of the availability of new evidence.
References
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Journal Article
American society of health-system pharmacists.
TL;DR: Funding is proposed for the purchase of a water filtration system for the authors' pantry, the recycling of office supplies, and the elimination of Styrofoam cups from the lunch room.
Journal ArticleDOI
Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome.
TL;DR: The results suggest that the exposures investigated, other than cytostatic drugs, do not cause a strong reproductive risk and further studies are needed.
Journal ArticleDOI
A study of occupational exposure to antineoplastic drugs and fetal loss in nurses.
Sherry G. Selevan,Sherry G. Selevan,Marja Liisa Lindbohm,Marja Liisa Lindbohm,Richard W. Hornung,Richard W. Hornung,Kari Hemminki +6 more
TL;DR: The results of this study suggest that caution be exercised in the handling of these valuable drugs, although the independent effect of each individual drug could not be specifically identified, since many nurses reported handling more than one of these agents.
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Occupational exposure to antineoplastic agents at several departments in a hospital. Environmental contamination and excretion of cyclophosphamide and ifosfamide in urine of exposed workers.
TL;DR: The occupational exposure to cyclophosphamide (CP), ifosfamide (IF), 5-fluorouracil (5FU), and methotrexate (MTX) of 25 pharmacy technicians and nurses from four departments of a hospital was investigated as discussed by the authors.