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Journal ArticleDOI

Retinal vessel segmentation by improved matched filtering: evaluation on a new high-resolution fundus image database

TLDR
The concept of matched filtering is improved, and the proposed blood vessel segmentation approach is at least comparable with recent state-of-the-art methods, and outperforms most of them with an accuracy of 95% evaluated on the new database.
Abstract
Automatic assessment of retinal vessels plays an important role in the diagnosis of various eye, as well as systemic diseases. A public screening is highly desirable for prompt and effective treatment, since such diseases need to be diagnosed at an early stage. Automated and accurate segmentation of the retinal blood vessel tree is one of the challenging tasks in the computer-aided analysis of fundus images today. We improve the concept of matched filtering, and propose a novel and accurate method for segmenting retinal vessels. Our goal is to be able to segment blood vessels with varying vessel diameters in high-resolution colour fundus images. All recent authors compare their vessel segmentation results to each other using only low-resolution retinal image databases. Consequently, we provide a new publicly available high-resolution fundus image database of healthy and pathological retinas. Our performance evaluation shows that the proposed blood vessel segmentation approach is at least comparable with recent state-of-the-art methods. It outperforms most of them with an accuracy of 95% evaluated on the new database.

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Citations
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Journal ArticleDOI

A Dataset and a Technique for Generalized Nuclear Segmentation for Computational Pathology

TL;DR: A large publicly accessible data set of hematoxylin and eosin (H&E)-stained tissue images with more than 21000 painstakingly annotated nuclear boundaries is introduced, whose quality was validated by a medical doctor.
Journal ArticleDOI

A Cross-Modality Learning Approach for Vessel Segmentation in Retinal Images

TL;DR: A wide and deep neural network with strong induction ability is proposed to model the transformation, and an efficient training strategy is presented, where instead of a single label of the center pixel, the network can output the label map of all pixels for a given image patch.
Journal ArticleDOI

DUNet: A deformable network for retinal vessel segmentation

TL;DR: Wang et al. as discussed by the authors proposed Deformable U-Net (DUNet), which exploits the retinal vessels' local features with a U-shape architecture, in an end-to-end manner for retinal vessel segmentation.
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A Discriminatively Trained Fully Connected Conditional Random Field Model for Blood Vessel Segmentation in Fundus Images

TL;DR: Results suggest that this method for blood vessel segmentation in fundus images based on a discriminatively trained fully connected conditional random field model is suitable for the task of segmenting elongated structures, a feature that can be exploited to contribute with other medical and biological applications.
Journal ArticleDOI

Robust Vessel Segmentation in Fundus Images

TL;DR: A method to reduce calculation time, achieve high accuracy, and increase sensitivity compared to the original Frangi method is presented and a new high resolution fundus database is proposed to compare it to the state-of-the-art algorithms.
References
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TL;DR: The purpose of this article is to serve as an introduction to ROC graphs and as a guide for using them in research.
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Survey over image thresholding techniques and quantitative performance evaluation

TL;DR: 40 selected thresholding methods from various categories are compared in the context of nondestructive testing applications as well as for document images, and the thresholding algorithms that perform uniformly better over nonde- structive testing and document image applications are identified.
Journal ArticleDOI

Ridge-based vessel segmentation in color images of the retina

TL;DR: A method is presented for automated segmentation of vessels in two-dimensional color images of the retina based on extraction of image ridges, which coincide approximately with vessel centerlines, which is compared with two recently published rule-based methods.
Journal ArticleDOI

Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response

TL;DR: An automated method to locate and outline blood vessels in images of the ocular fundus that uses local and global vessel features cooperatively to segment the vessel network is described.
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