Review of the epidemiology of overactive bladder.
Renu S Eapen,Sidney B. Radomski +1 more
TLDR
This review examines the major studies that looked at the epidemiology of OAB as it relates to both sexes and addresses the level of bother and quality of life in men and women with OAB.Abstract:
Overactive bladder (OAB) is common in both men and women. It is a symptom complex that causes significant detriment to quality of life in patients. Although the prevalence of OAB is similar in both sexes, there are sex-specific differences in individual symptoms and the impact on quality of life. The coexistence of benign prostatic hyperplasia with OAB can worsen quality of life in men. This review examines the major studies that looked at the epidemiology of OAB as it relates to both sexes. It focuses on both the overall prevalence rates and the incidence of individual symptoms. This paper also addresses the level of bother and quality of life in men and women with OAB. In addition, the relationship between OAB and benign prostatic hyperplasia is reviewed.read more
Citations
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Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs.
Ying Hong Li,Xiao Xu Li,Xiao Xu Li,Jia Jun Hong,Yun Xia Wang,Jian Bo Fu,Hong Yang,Chun Yan Yu,Feng Cheng Li,Jie Hu,Weiwei Xue,Yuyang Jiang,Yu Zong Chen,Feng Zhu,Feng Zhu +14 more
TL;DR: A comprehensive analysis of all 89 innovative targets of first-in-class drugs approved in 2004–17 confirmed the literature-reported common druggability characteristics for clinical success of these innovative targets, exposed trial-speed differentiating features associated to the on-target and off-target collateral effects in humans and revealed a simple rule for identifying the speedy human targets through clinical trials.
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Real-world persistence and adherence to oral antimuscarinics and mirabegron in patients with overactive bladder (OAB): a systematic literature review
TL;DR: Most patients with OAB discontinued oral OAB pharmacotherapy and were non-adherent 1 year after treatment initiation, and in general, mirabegron was associated with greater persistence and adherence compared with antimuscarinics.
Journal ArticleDOI
The prevalence of lower urinary tract symptoms (LUTS) in Brazil: Results from the epidemiology of LUTS (Brazil LUTS) study.
TL;DR: The first large population‐based study to evaluate lower urinary tract symptoms (LUTS) in Brazil and the prevalence and bother of LUTS in the population aged ≥40 years in five major cities of Brazil is performed.
Journal ArticleDOI
A Systematic Review of Mycoplasma and Ureaplasma in Urogynaecology.
Nina Combaz-Söhnchen,A. Kuhn +1 more
TL;DR: A urethral swab for PCR analysis of the three bacteria should be performed in the context of symptomatic sterile leukocyturia, chronic urethritis and suspected hyperactive bladder or interstitial cystitis/painful bladder syndrome to provide clinical guidance on diagnosis and treatment.
Journal ArticleDOI
Prevalence and bother of lower urinary tract symptoms and overactive bladder in Poland, an Eastern European Study.
TL;DR: LUTS were highly prevalent, often bothersome, and had negative effects on the quality of life of men and women aged ≥ 40 years in Poland, and the findings are comparable with other epidemiologic studies of LUTS and OAB conducted in different regions of the world.
References
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Journal ArticleDOI
Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study
Debra E. Irwin,Ian Milsom,Steinar Hunskaar,Kate Reilly,Zoe Kopp,Sender Herschorn,Karin S. Coyne,Con Kelleher,Christian Hampel,Walter Artibani,Paul Abrams +10 more
TL;DR: The EPIC study is the largest population-based survey to assess prevalence rates of OAB, UI, and other LUTS in five countries and is the first study to evaluate these symptoms simultaneously using the 2002 ICS definitions.
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Prevalence and burden of overactive bladder in the United States
Walter F. Stewart,J B Van Rooyen,Geoffrey W. Cundiff,Paul Abrams,A R Herzog,R Corey,Timothy L. Hunt,Alan J. Wein +7 more
TL;DR: The NOBLE studies do not support the commonly held notion that women are considerably more likely than men to have urgency-related bladder control problems, and overactive bladder, with and without urge incontinence, has a clinically significant impact on quality-of-life, quality- of-sleep, and mental health, in both men and women.
Journal ArticleDOI
How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study.
TL;DR: The prevalence of chronic and debilitating symptoms of the overactive bladder are determined as the presence of chronic frequency, urgency and urge incontinence (either alone or in any combination), and presumed to be caused by involuntary detrusor contractions.
Journal ArticleDOI
National community prevalence of overactive bladder in the United States stratified by sex and age.
TL;DR: Bothersome OAB symptoms are highly prevalent among men and women aged ≥40 years in the United States, and it is estimated that 29.8 million adults aged ≥ 40 years in a cross-sectional, population-representative survey have bothersomeOAB symptoms.
Journal ArticleDOI
Safety and tolerability of tolterodine for the treatment of overactive bladder in men with bladder outlet obstruction.
TL;DR: Tolterodine did not adversely affect urinary function in men with OAB and BOO, and there was no evidence of clinically meaningful changes in voiding pressure and PVR or urinary retention.