Risk factors for central and branch retinal vein occlusion: a meta-analysis of published clinical data
TLDR
Individuals with end-organ damage caused by diabetes mellitus and hypertension have greatly increased risk for RVO, and Socioeconomic status seems to be a risk factor too.Abstract:
Retinal vein occlusion (RVO) is a major cause of vision loss. Of the two main types of RVO, branch retinal vein occlusion (BRVO) is 4 to 6 times more prevalent than central retinal vein occlusion (CRVO). A basic risk factor for RVO is advancing age. Further risk factors include systemic conditions like hypertension, arteriosclerosis, diabetes mellitus, hyperlipidemia, vascular cerebral stroke, blood hyperviscosity, and thrombophilia. A strong risk factor for RVO is the metabolic syndrome (hypertension, diabetes mellitus, and hyperlipidemia). Individuals with end-organ damage caused by diabetes mellitus and hypertension have greatly increased risk for RVO. Socioeconomic status seems to be a risk factor too. American blacks are more often diagnosed with RVO than non-Hispanic whites. Females are, according to some studies, at lower risk than men. The role of thrombophilic risk factors in RVO is still controversial. Congenital thrombophilic diseases like factor V Leiden mutation, hyperhomocysteinemia and anticardiolipin antibodies increase the risk of RVO. Cigarette smoking also increases the risk of RVO as do systemic inflammatory conditions like vasculitis and Behcet disease. Ophthalmic risk factors for RVO are ocular hypertension and glaucoma, higher ocular perfusion pressure, and changes in the retinal arteries.read more
Citations
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Journal ArticleDOI
Smoke and autoimmunity: The fire behind the disease.
Carlo Perricone,Mathilde Versini,Dana Ben-Ami,Smadar Gertel,Abdulla Watad,Michael J. Segel,Fulvia Ceccarelli,Fabrizio Conti,Luca Cantarini,Dimitrios P. Bogdanos,Alessandro Antonelli,Howard Amital,Guido Valesini,Yehuda Shoenfeld +13 more
TL;DR: The association between smoke habit and autoimmunity has been hypothesized a long time ago and large epidemiological studies are needed to further explore the accountability of smoking effect in the pathogenesis of autoimmune diseases.
Journal ArticleDOI
Global epidemiology of retinal vein occlusion: a systematic review and meta-analysis of prevalence, incidence, and risk factors
TL;DR: This study provides an updated summary of RVO epidemiology in the general population and indicates that more epidemiological studies worldwide are still needed to better understand the global disease burden of R VO.
Journal ArticleDOI
Prevalence and risk factors of retinal vein occlusion: the Gutenberg Health Study.
Katharina A. Ponto,H Elbaz,H Elbaz,H Elbaz,Tunde Peto,Dagmar Laubert-Reh,Harald Binder,Philipp S. Wild,K.J. Lackner,Norbert Pfeiffer,Alireza Mirshahi +10 more
TL;DR: To determine the age‐ and sex‐specific prevalence and determinants of retinal vein occlusions (RVOs) in a large population‐based German cohort, data are presented on RVOs in men and women aged between 18 and 74 years.
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Individualized Ranibizumab Regimen Driven by Stabilization Criteria for Central Retinal Vein Occlusion: Twelve-Month Results of the CRYSTAL Study.
Michael Larsen,Sebastian M. Waldstein,Francesco Boscia,Heinrich Gerding,Jordi Monés,Ramin Tadayoni,Siegfried G. Priglinger,Andreas Wenzel,Elizabeth Barnes,Stefan Pilz,William John Stubbings,Ian Pearce +11 more
TL;DR: An individualized dosing regimen of ranibizumab 0.5 mg driven by stabilization criteria for up to 12 months resulted in significant BCVA gain in a broad population of patients with macular edema secondary to CRVO, including those with macULAR ischemia at baseline.
Journal ArticleDOI
Blood flow mechanics and oxygen transport and delivery in the retinal microcirculation: multiscale mathematical modeling and numerical simulation
Paola Causin,Giovanna Guidoboni,Giovanna Guidoboni,Francesca Malgaroli,Riccardo Sacco,Alon Harris +5 more
TL;DR: A novel mathematical and computational model describes the coupling between blood flow mechanics and oxygen transport in the retina and shows that systemic arterial blood pressure has a strong influence on the retinal circulation profiles in both blood and tissue.
References
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Journal ArticleDOI
The Prevalence of Retinal Vein Occlusion: Pooled Data from Population Studies from the United States, Europe, Asia, and Australia
Sophie Rogers,Rachel McIntosh,Ning Cheung,Lyndell L Lim,Jie Jin Wang,Jie Jin Wang,Paul Mitchell,Jonathan W. Kowalski,Hiep Nguyen,Tien Yin Wong,Tien Yin Wong +10 more
TL;DR: The study provides summary data on the prevalence of RVO and suggests that approximately 16 million people may have this condition and research on preventive and treatment strategies for this sight-threatening eye disease is needed.
Journal Article
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TL;DR: The data suggest a strong association between retinal branch vein occlusion and retinal arteriolar changes, and data from larger populations are needed to further assess associations between risk factors and the incidence of retinal vein Occlusion.
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Prevalence and associations of retinal vein occlusion in Australia : The blue mountains eye study
TL;DR: The proportion of the 3 vein occlusion sites shows some differences from those of clinic-based reports and suggests a likely selection bias in previous clinic studies.
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Incidence of Various Types of Retinal Vein Occlusion and Their Recurrence and Demographic Characteristics
TL;DR: Retinal vein occlusion occurred more often in men than women; however, 99 of 620 (16%), 15 of 154 (10%), and 17 of 375 (5%) of the patients with central, hemicentral, and branch retinal vein Occlusion, respectively, were younger than 45 years.
Journal ArticleDOI
Prevalent misconceptions about acute retinal vascular occlusive disorders
TL;DR: The objective of this paper is to discuss misconceptions on acute retinal vascular occlusion, to clarify the understanding of these disorders, and place their management in the context of blinding disorders.