Role of human milk in extremely low birth weight infants’ risk of necrotizing enterocolitis or death
Jareen Meinzen-Derr,Brenda B. Poindexter,Lisa A. Wrage,Ardythe L. Morrow,Barbara J. Stoll,Edward F. Donovan +5 more
TLDR
Data suggest a dose-related association of HM feeding with a reduction of risk of NEC or death after the first 2 weeks of life among extremely low birth weight infants.Abstract:
To determine the association between human milk (HM) intake and risk of necrotizing enterocolitis (NEC) or death among infants 401 to 1000 g birth weight. Analysis of 1272 infants in the National Institute of Child Health and Human Development Neonatal Network Glutamine Trial was performed to determine if increasing HM intake was associated with decreased risk of NEC or death. HM intake was defined as the proportion of HM to total intake, to enteral intake and total volume over the first 14 days. Known NEC risk factors were included as covariates in Cox proportional hazard analyses for duration of survival time free of NEC. Among study infants, 13.6% died or developed NEC after 14 days. The likelihood of NEC or death after 14 days was decreased by a factor of 0.83 (95% confidence interval, CI 0.72, 0.96) for each 10% increase in the proportion of total intake as HM. Each 100 ml kg−1 increase in HM intake during the first 14 days was associated with decreased risk of NEC or death (hazard ratio, HR 0.87 (95% CI 0.77, 0.97)). There appeared to be a trend towards a decreased risk of NEC or death among infants who received 100% HM as a proportion to total enteral intake (HM plus formula), although this finding was not statistically significant (HR 0.85 (95% CI 0.60, 1.19)). These data suggest a dose-related association of HM feeding with a reduction of risk of NEC or death after the first 2 weeks of life among extremely low birth weight infants.read more
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Breastfeeding and the Use of Human Milk
TL;DR: Pediatricians play a critical role in their practices and communities as advocates of breastfeeding and thus should be knowledgeable about the health risks of not breastfeeding, the economic benefits to society of breastfeeding, and the techniques for managing and supporting the breastfeeding dyad.
Journal ArticleDOI
An Exclusively Human Milk-Based Diet Is Associated with a Lower Rate of Necrotizing Enterocolitis than a Diet of Human Milk and Bovine Milk-Based Products
Sandra E. Sullivan,Richard J. Schanler,Jae H. Kim,Aloka L. Patel,Rudolf Trawöger,Ursula Kiechl-Kohlendorfer,Gary M. Chan,Cynthia L. Blanco,Steven A. Abrams,C. Michael Cotten,Nirupama Laroia,Richard A. Ehrenkranz,Golde Dudell,Elizabeth Cristofalo,Paula P. Meier,Martin Lee,David J. Rechtman,Alan Lucas +17 more
TL;DR: For extremely premature infants, an exclusively human milk-based diet is associated with significantly lower rates of NEC and surgical NEC when compared with a mother's milk- based diet that also includes bovine Milk-based products.
Journal ArticleDOI
Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature Infants
Venkata S. Kuppala,Jareen Meinzen-Derr,Jareen Meinzen-Derr,Ardythe L. Morrow,Ardythe L. Morrow,Kurt Schibler,Kurt Schibler +6 more
TL;DR: In this article, the outcomes after prolonged empirical antibiotic administration to premature infants in the first week of life were investigated, and concluding subsequent late onset sepsis (LOS), necrotizing enterocolitis (NEC), and death.
Journal ArticleDOI
Necrotizing enterocolitis: have we made any progress in reducing the risk?
TL;DR: The pathophysiology and causes of NEC are discussed, and the development of several strategies investigated regarding risk reduction of this devastating disease are presented.
Journal ArticleDOI
Donor human milk for preterm infants: current evidence and research directions.
Sertac Arslanoglu,Willemijn E. Corpeleijn,Willemijn E. Corpeleijn,Guido E. Moro,Christian Braegger,Cristina Campoy,Virginie Colomb,Tamás Decsi,Magnus Domellöf,Mary Fewtrell,Iva Hojsak,Walter A. Mihatsch,Christian Mølgaard,Raanan Shamir,Dominique Turck,Johannes B. van Goudoever +15 more
TL;DR: This commentary emphasizes that fresh own mother's milk (OMM) is the first choice in preterm infant feeding and strong efforts should be made to promote lactation.
References
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Journal ArticleDOI
Breastfeeding and the Use of Human Milk
TL;DR: Pediatricians play a critical role in their practices and communities as advocates of breastfeeding and thus should be knowledgeable about the health risks of not breastfeeding, the economic benefits to society of breastfeeding, and the techniques for managing and supporting the breastfeeding dyad.
Journal ArticleDOI
Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging
Martin J. Bell,Jessie L. Ternberg,Ralph D. Feigin,James P. Keating,Richard Marshall,Leslie L. Barton,Thomas Brotherton +6 more
TL;DR: These studies support the use of combination antimicrobial therapy in the treatment of infants with NEC and suggest vigorous diagnostic and supportive measures are appropriate for Stage I infants.
Journal ArticleDOI
Breastfeeding and the use of human milk
Journal ArticleDOI
Breast milk and neonatal necrotising enterocolitis
Alan Lucas,Tim J Cole +1 more
TL;DR: With the fall in the use of breast milk in British neonatal units, exclusive formula feeding could account for an estimated 500 extra cases of necrotising enterocolitis each year, and about 100 infants would die.
Journal ArticleDOI
Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network.
James A. Lemons,Charles R. Bauer,William Oh,S B Korones,Lu-Ann Papile,Barbara J. Stoll,Joel Verter,Marinella Temprosa,Linda L. Wright,Richard A. Ehrenkranz,Avroy A. Fanaroff,Ann R. Stark,Waldemar A. Carlo,Jon E. Tyson,Edward F. Donovan,Seetha Shankaran,David K. Stevenson +16 more
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