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Open AccessJournal ArticleDOI

Some medicolegal aspects concerning tramadol abuse: The new Middle East youth plague 2010. An Egyptian overview

Marwa M Fawzi
- 01 Jun 2011 - 
- Vol. 1, Iss: 2, pp 99-102
TLDR
The significantly notable increasing violence forms are closely related to drug abuse and tramadol’s prevalence is the mostly noted due to its wider availability and cheaper prices than other types of abused drugs.
Abstract
An increasingly alarming phenomenon of tramadol drug abuse has been demonstrated in the Egyptian community. The alleged usages of tramadol had also contributed greatly to its popularity and massive use especially among Egyptian youth as a remedy for premature ejaculatory function and for extended orgasm and increase sexual pleasure as promoted through many online drug stores and media. 1 Aim of the work To study the impact of tramadol and its increasing rates of drug abuse widely spread among Egyptian youth on the observed association with recently increasingly noted variable forms of aggression and accidents. Patients and methods This study was carried out on the patients who presented to (PCC-ASU) Hospitals, Egypt in the year 2010 (January–December). Results The total number of studied cases was 640 with the adult (67.9%), males (77.2%). Abuse form of drug intake was the highest (50.8%). Oral intake (96.8%). The most frequent forms of injuries were cerebral edema (55.9%). Conclusions The significantly notable increasing violence forms are closely related to drug abuse. Tramadol’s prevalence is the mostly noted due to its wider availability and cheaper prices than other types of abused drugs. The unplanned indirect media advertising for tramadol abuse through movies and show series also played a remarkable role in promoting tramadol abuse. Recommendations Drug screening for tramadol should be added to all forms of basic toxicological screening. Especially in cases of patients involved in violent crimes and road traffic accidents, also for those applying for drivers’ license fitness program.

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Citations
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Journal ArticleDOI

Adolescent tramadol use and abuse in Egypt.

TL;DR: Tamadol use was common among adolescents and over one third of tramadol users had drug-related problems, and there was a significant association between tramdol use and older age, male gender, and smoking.
Journal ArticleDOI

Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures.

TL;DR: The objective is to summarize the literature on the pharmacology, epidemiology, risk factors, clinical presentations, and evidence-based management of tramadol-related seizures and serotonin syndrome.
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Chronic exposure to the opioid tramadol induces oxidative damage, inflammation and apoptosis, and alters cerebral monoamine neurotransmitters in rats.

TL;DR: The results indicate that the neurotoxic effect of chronic tramadol consumption is mediated via oxidative stress, inflammation and apoptosis, and changes in monoamine neurotransmitters.
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Substance use disorders in Arab countries: research activity and bibliometric analysis

TL;DR: The results obtained suggest that research in this field was largely neglected in the past, however, recent research interest was observed and research output on tobacco and smoking was relatively high compared to other substances of abuse like illicit drugs and medicinal agents.
References
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Journal ArticleDOI

Pharmacologie du tramadol

TL;DR: A monoaminergic activity that inhibits noradrenaline (norepinephrine) and serotonin (5-hydroxytryptamine; 5-HT) reuptake is demonstrated, making a significant contribution to the analgesic action by blocking nociceptive impulses at the spinal level.
Journal ArticleDOI

ORIGINAL RESEARCH–EJACULATORY DISORDERS: Tramadol HCL has Promise in On-Demand Use to Treat Premature Ejaculation

TL;DR: Tramadol, a drug with a proven safety record as an anti-inflammatory agent, shows promise as a drug for treating rapid ejaculation.
Journal ArticleDOI

Tramadol Exposures Reported to Statewide Poison Control System

TL;DR: Tramadol overdoses frequently cause CNS depression, nausea/vomiting, tachycardia, and seizures, and symptoms generally resolve within 24 hours, primarily causing sedation.
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Fatal overdoses of tramadol: is benzodiazepine a risk factor of lethality?

TL;DR: The toxicity of tramadol, the detection method and the possible interaction with other central nervous system (CNS) depressants, particularly benzodiazepines are assessed and a possible cytochrome P450-based interaction between tramadl and benzodiazine is considered.
Journal ArticleDOI

Serotonin syndrome associated with tramadol.

TL;DR: This case illustrates an example of a toxic overdose with tramadol that resulted in features suggestive of serotonin syndrome, the first reported case in which serotonin syndrome was associated with tramadol alone without concomitant use of other serotonergic medications.
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