Journal ArticleDOI
Standardized surgery for colonic cancer: complete mesocolic excision and central ligation--technical notes and outcome.
TLDR
This technique is focused on an intact package of the tumour and its main lymphatic drainage and this technique is nowadays accepted worldwide for optimal rectal cancer surgery.Abstract:
Objective Total mesorectal excision (TME) as proposed by R.J. Heald more than 20 years ago, is nowadays accepted worldwide for optimal rectal cancer surgery. This technique is focused on an intact package of the tumour and its main lymphatic drainage.
This concept can be translated into colon cancer surgery, as the mesorectum is only part of the mesenteric planes which cover the colon and its lymphatic drainage like envelopes. According to the concept of TME for rectal cancer, we perform a concept of complete mesocolic excision (CME) for colonic cancer. This technique aims at the separation of the mesocolic from the parietal plane and true central ligation of the supplying arteries and draining veins right at their roots.
Method Prospectively obtained data from 1329 consecutive patients of our department with RO-resection of colon cancer between 1978 and 2002 were analysed. Patient data of three subdivided time periods were compared.
Results By consequent application of the procedure of CME, we were able to reduce local 5-year recurrence rates in colon cancer from 6.5% in the period from 1978 to 1984 to 3.6% in 1995 to 2002. In the same period, the cancer related 5-year survival rates in patients resected for cure increased from 82.1% to 89.1%.
Conclusion The technique of CME in colon cancer surgery aims at a specimen with intact layers and a maximum of lymphnode harvest. This is translated into lower local recurrence rates and better overall survival.read more
Citations
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Journal ArticleDOI
Lymph node yield, survival benefit, and safety of high and low ligation of the inferior mesenteric artery in colorectal cancer surgery: a systematic review and meta-analysis.
Moubo Si,Peijing Yan,Zhen-Ying Du,Laiyuan Li,Hongwei Tian,Wen-Jie Jiang,Wutang Jing,Jia Yang,Caiwen Han,Xiue Shi,Kehu Yang,Tiankang Guo +11 more
TL;DR: LL can achieve equivalent lymph node yield to HL, and both procedures have similar survival benefits, however, LL is associated with a lower incidence of leakage and urethral dysfunction, and LL is recommended for colorectal cancer surgery.
Journal ArticleDOI
Robotic Surgery for Colon and Rectal Cancer
Eun Jung Park,Seung Hyuk Baik +1 more
TL;DR: As the technical advances in robotic surgery improve surgical performance as well as outcomes, it increasingly is being regarded as a treatment option for colorectal surgery, however, a multicenter, randomized clinical trial is needed to validate this approach.
Journal ArticleDOI
Feasibility and Safety of Laparoscopic Complete Mesocolic Excision (CME) for Right-sided Colon Cancer: Short-term Outcomes. A Randomized Clinical Study.
Giuseppe Di Buono,Salvatore Buscemi,Gianfranco Cocorullo,Vincenzo Sorce,Giuseppe Amato,Giulia Bonventre,Elisa Maienza,Massimo Galia,Leonardo Gulotta,Giorgio Romano,Antonino Agrusa +10 more
TL;DR: In this study laparoscopic CME were a safe and feasible technique with improvement in lymph nodes harvesting and length of surgical specimens with no increase of surgical intraoperative and postoperative complications.
Journal ArticleDOI
No benefit of extended mesenteric resection with central vascular ligation in right-sided colon cancer
TL;DR: This study compares the short‐ and long‐term outcome in three variations of right hemicolectomy based on the position of the vascular ligature in the mesentery to find the optimal extent of mesenteric resection in colon cancer surgery.
Journal ArticleDOI
CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phase II trial.
Fangqi Liu,Li Yang,Yuchen Wu,Cong Li,Jiang Zhao,Adili Keranmu,Hongtu Zheng,Dan Huang,Lei Wang,Tong Tong,Junyan Xu,Ji Zhu,Sanjun Cai,Ye Xu +13 more
TL;DR: The results suggest that NAC with CapOX is an effective and safe treatment option for patients with locally advanced CCs.
References
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Journal ArticleDOI
Global cancer statistics, 2002.
TL;DR: There are striking variations in the risk of different cancers by geographic area, most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
Journal ArticleDOI
Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer
Rolf Sauer,Heinz Becker,Werner Hohenberger,Claus Rödel,Christian Wittekind,Rainer Fietkau,Peter Martus,Jörg Tschmelitsch,Eva Hager,Clemens F. Hess,Torsten Liersch,Heinz Schmidberger,Rudolf Raab +12 more
TL;DR: Preoperative chemoradiotherapy, as compared with postoperative cheMoradi therapy, improved local control and was associated with reduced toxicity but did not improve overall survival.
Journal ArticleDOI
Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer
Thierry André,Corrado Boni,Lamia Mounedji-Boudiaf,Matilde Navarro,Josep Tabernero,Tamas Hickish,C. Topham,Marta Zaninelli,Phillip Clingan,John Bridgewater,Isabelle Tabah-Fisch,Aimery de Gramont +11 more
TL;DR: Adding oxaliplatin to a regimen of fluorouracil and leucovorin improves the adjuvant treatment of colon cancer.
Journal ArticleDOI
Chemotherapy with preoperative radiotherapy in rectal cancer
Jean-François Bosset,Laurence Collette,Gilles Calais,Laurent Mineur,Philippe Maingon,L. Radosevic-Jelic,Alain Daban,Etienne Bardet,Alexander Beny,Jean-Claude Ollier +9 more
TL;DR: In patients with rectal cancer who receive preoperative radiotherapy, adding fluorouracil-based chemotherapy preoperatively or postoperatively has no significant effect on survival.
Journal ArticleDOI
Colon Cancer Survival Rates With the New American Joint Committee on Cancer Sixth Edition Staging
TL;DR: The association of stage IIIa colon cancer with statistically significantly better survival than stage IIb in the new system may reflect current clinical practice, in which stage III patients receive chemotherapy but stage II patients generally do not.
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