Synchronous oscillations in neuronal systems: mechanisms and functions.

TLDR: New techniques have revealed that spatially and temporally organized activity among distributed populations of cells often takes the form of synchronous rhythms, which provide new insights into the behavior and mechanisms controUing the coordination of activity in neuronal populations.

Abstract: How are the functions performed by one part of the nervous system integrated with those of another? This fundamental issue pervades virtually every aspect of brain function from sensory and cognitive processing to motor control. Yet from a physiological perspective we know very little about the neural mechanisms underlying the integration of distributed processes in the nervous system. Even the simplest of sensori-motor acts engages vast numbers of cells in many different parts of the brain. Such actions require coordination between a host of neural systems, each of which must carry out parallel computations involving large populations of interconnected neurons. It seems reasonable to assume that a mechanism or class of mechanisms has evolved to temporally coordinate the activity within and between subsystems of the central nervous system. For several reasons, neuronal rhythms have long been thought to play an important role in such coordination. Since the discovery of the Electroencephalogram (EEG) over 60 years ago it has been known that a number of structures in the mammalian brain engage in rhythmic activities. These patterned neuronal oscillations take many forms. They occur over a broad range of frequencies, and are present in a multitude of different systems in the b~ain, during a variety of different behavioral states. They are often the most salient aspect of observable electrical activity in the brain and typically encompass widespread regions of cerebral tissue. With the advent of new techniques of multielectrode recording and neural imaging, it is now within the realm of possibility 'to record from 100 single neurons simultaneously (Wilson and McNaughton, 1993), to optically measure the activity in a cortical area (Blasdel and Salama, 1986; T'so et al., 1990), or to noninvasively image the pattern of electric current flow in an alert human being performing a task (Pantev et al., 1991). These new techniques have revealed that spatially and temporally organized activity among distributed populations of cells often takes the form of synchronous rhythms. When combined with cellular neurophysiological and anatomical studies these findings provide new insights into the behavior and mechanisms controUing the coordination of activity in neuronal populations.