The benefits and risks of testosterone replacement therapy: a review
Reads0
Chats0
TLDR
Although controversy remains regarding indications for testosterone supplementation in aging men due to lack of large-scale, long-term studies assessing the benefits and risks of testosterone-replacement therapy in men, reports indicate that TRT may produce a wide range of benefits for men with hypogonadism that include improvement in libido and sexual function.Abstract:
Increased longevity and population aging will increase the number of men with late onset hypogonadism. It is a common condition, but often underdiagnosed and undertreated. The indication of testosterone-replacement therapy (TRT) treatment requires the presence of low testosterone level, and symptoms and signs of hypogonadism. Although controversy remains regarding indications for testosterone supplementation in aging men due to lack of large-scale, long-term studies assessing the benefits and risks of testosterone-replacement therapy in men, reports indicate that TRT may produce a wide range of benefits for men with hypogonadism that include improvement in libido and sexual function, bone density, muscle mass, body composition, mood, erythropoiesis, cognition, quality of life and cardiovascular disease. Perhaps the most controversial area is the issue of risk, especially possible stimulation of prostate cancer by testosterone, even though no evidence to support this risk exists. Other possible risks include worsening symptoms of benign prostatic hypertrophy, liver toxicity, hyperviscosity, erythrocytosis, worsening untreated sleep apnea or severe heart failure. Despite this controversy, testosterone supplementation in the United States has increased substantially over the past several years. The physician should discuss with the patient the potential benefits and risks of TRT. The purpose of this review is to discuss what is known and not known regarding the benefits and risks of TRT.read more
Citations
More filters
Journal ArticleDOI
Review article: sarcopenia in cirrhosis – aetiology, implications and potential therapeutic interventions
Marie Sinclair,Marie Sinclair,Paul J Gow,Paul J Gow,Mathis Grossmann,Mathis Grossmann,Peter W Angus,Peter W Angus +7 more
TL;DR: Current teaching recommends the use of protein supplementation and exercise, however, this fails to address many other factors which contribute to muscle loss in this setting.
Journal ArticleDOI
Testosterone and the Cardiovascular System: A Comprehensive Review of the Clinical Literature
Peyman Mesbah Oskui,Peyman Mesbah Oskui,William J. French,Michael J. Herring,Guy S Mayeda,Guy S Mayeda,Guy S Mayeda,Steven Burstein,Steven Burstein,Robert A. Kloner,Robert A. Kloner +10 more
TL;DR: A large number of men aged 40 to 69 in the United States suffer from hypogonadism, and the number of these men is likely to increase as they age.
Journal ArticleDOI
The dominance behavioral system and psychopathology: evidence from self-report, observational, and biological studies.
TL;DR: Suggestions for future research on the DBS and psychopathology are provided, including investigations of the potential usefulness of DBS in differentiating specific disorder outcomes, the need for more sophisticated biological research, and the value of longitudinal dynamical research.
Journal ArticleDOI
The hypoxic testicle: physiology and pathophysiology.
Juan G. Reyes,Jorge G. Farías,Sebastián Henríquez-Olavarrieta,Eva Madrid,Mario Párraga,Andrea B. Zepeda,Ricardo D. Moreno +6 more
TL;DR: It is suggested that conditions such as germ cell apoptosis and DNA damage are common features in hypoxia and varicocele and testicular torsion and oxidative damage seems to be present in these conditions during the initiation stages of germ cell damage and apoptosis.
Journal ArticleDOI
Urinary Phthalate Metabolites Are Associated With Decreased Serum Testosterone in Men, Women, and Children From NHANES 2011–2012
John D. Meeker,Kelly K. Ferguson +1 more
TL;DR: Because T plays an important role in all life stages for both sexes, future efforts should focus on better defining these relationships and their broader impacts.
References
More filters
Journal ArticleDOI
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
TL;DR: The FT value, obtained by calculation from T and SHBG as determined by immunoassay, appears to be a rapid, simple, and reliable index of bioavailable T, comparable to AFTC and suitable for clinical routine, except in pregnancy.
Journal ArticleDOI
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
TL;DR: Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
Journal ArticleDOI
Age Trends in the Level of Serum Testosterone and Other Hormones in Middle-Aged Men: Longitudinal Results from the Massachusetts Male Aging Study
Henry A. Feldman,Christopher Longcope,Carol A. Derby,Catherine B. Johannes,Andre B. Araujo,Andrea D. Coviello,William J. Bremner,John B. McKinlay +7 more
TL;DR: The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels.
Journal ArticleDOI
Aging of skeletal muscle: a 12-yr longitudinal study
Walter R. Frontera,Virginia A. Hughes,Roger A. Fielding,Roger A. Fielding,Maria A. Fiatarone,Maria A. Fiatarone,William J. Evans,Ronenn Roubenoff +7 more
TL;DR: It is suggested that a quantitative loss in muscle CSA is a major contributor to the decrease in muscle strength seen with advancing age and accounts for 90% of the variability in strength at T2.
Journal ArticleDOI
Sex Differences of Endogenous Sex Hormones and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis
TL;DR: In this paper, a systematic review indicates that endogenous sex hormones may differentially modulate glycemic status and risk of type 2 diabetes in men and women, while the inverse association of SHBG with risk was stronger in women than in men.
Related Papers (5)
Adverse Events Associated with Testosterone Administration
Shehzad Basaria,Andrea D. Coviello,Thomas G. Travison,Thomas W. Storer,Wildon Farwell,Wildon Farwell,Alan M. Jette,Richard Eder,Sharon L. Tennstedt,Jagadish Ulloor,Anqi Zhang,Karen Choong,Kishore M. Lakshman,Norman A. Mazer,Renee Miciek,Joanne B. Krasnoff,Ayan Elmi,Philip E. Knapp,Brad Brooks,Erica R. Appleman,Sheetal Aggarwal,Geeta Bhasin,Leif Hede-Brierley,Ashmeet Bhatia,Lauren Collins,Nathan K. LeBrasseur,Louis D. Fiore,Shalender Bhasin +27 more
Identification of late-onset hypogonadism in middle-aged and elderly men.
Frederick C. W. Wu,Abdelouahid Tajar,Jennifer M. Beynon,Stephen R Pye,Alan J. Silman,Joseph D. Finn,Terence W O'Neill,Gyorgy Bartfai,Felipe F. Casanueva,Gianni Forti,Aleksander Giwercman,Thang S. Han,Krzysztof Kula,Michael E. J. Lean,Neil Pendleton,Margus Punab,Steven Boonen,Dirk Vanderschueren,Fernand Labrie,Ilpo Huhtaniemi +19 more