The role of osteopontin in inflammatory processes
TLDR
Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification.Abstract:
Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN is involved in normal physiological processes and is implicated in the pathogenesis of a variety of disease states, including atherosclerosis, glomerulonephritis, cancer, and several chronic inflammatory diseases. Through interactions with several integrins, OPN mediates cell migration, adhesion, and survival in many cell types. OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification.read more
Citations
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Journal ArticleDOI
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.
TL;DR: Recent findings on the role of osteopontin in metabolic disorders, particularly focusing on diabetes and obesity are summarized.
Journal ArticleDOI
The multiple functions and mechanisms of osteopontin.
TL;DR: The aim of the present review is to address majority of different functions of OPN protein which are known, suspected or suggested through the data obtained about this protein yet.
CD44 variants but not CD44s cooperate with _1-containing′ integrins′ to permit cells to osteopontin independently of arginine-′ glycine-aspartic acid, thereby stimulating cell motility and′ chemotaxis.
T. Sleeman,H. Fujii,P. Herrich,H. Hotta,Kumiko Tanaka,S. Chikuma,H. Yagita,K. Okumura,M. ′ Murakami,I. Saiki,Ann F. Chambers,T. Uede +11 more
TL;DR: In this article, the authors show that osteopontin (OPN), CD44, and integrins cooperate to enhance cell motility and promote cell spreading, motility, and chemotactic behavior.
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Current trends in inflammatory and immunomodulatory mediators in sepsis
TL;DR: This review highlights the latest discoveries of the mediators in sepsis linking to innate and adaptive immune systems, which may lead to resolution of many unexplored queries.
Journal ArticleDOI
Emerging avenues linking inflammation and cancer
TL;DR: The multifaceted role of inflammation in carcinogenesis in the context of altered cellular redox signaling is highlighted and identified as the key molecular event in linking inflammation and cancer.
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Receptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
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Journal ArticleDOI
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease.
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