Journal ArticleDOI
The role of structure and molecular properties of terpenoids in determining their antimicrobial activity.
TLDR
The minimum inhibitory concentrations (MIC) of 60 terpenoids against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Candida albicans have been determined.Abstract:
The minimum inhibitory concentrations (MIC) of 60 terpenoids against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Candida albicans have been determined. Hierarchical cluster analysis was used to group the compounds into five groups according to their activity patterns against the four microorganisms. K-Means cluster analysis was then used to confirm these groupings and to show the differences in the activity patterns of the groups. Ten molecular properties of the terpenoids, either calculated via molecular modelling or determined by direct measurement, were then used as variables in a forward stepwise discriminant analysis to identify which variables discriminated between groups. Low water solubility of Group IV compounds, mainly hydrocarbons and acetates, was found to be associated with their relative inactivity. The remaining groups, all containing oxygenated terpenoids, showed characteristic but distinct activity patterns towards the four test organisms. Hydrogen bonding parameters were found to be associated with antimicrobial activity in all cases. Activity against Gram-negative E. coli and P. aeruginosa was associated with a combination of a hydrogen bonding and size parameters. This was not found to be the case for the Gram-positive S. aureus or the yeast C. albicans. Copyright © 1999 John Wiley & Sons, Ltd.read more
Citations
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Journal ArticleDOI
Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
TL;DR: This review summarizes recent developments in understanding of the antimicrobial and anti-inflammatory activities of the tea tree oil and its components, as well as clinical efficacy.
Journal ArticleDOI
Improvement in shelf-life and safety of perishable foods by plant essential oils and smoke antimicrobials
Richard A. Holley,Dhaval Patel +1 more
TL;DR: The potential value of natural antimicrobial agents from plants as secondary preservatives is considered as well as the effectiveness and use of similar aromatic and phenolic compounds in wood smoke for the safe extension of perishable food shelf-life.
Journal ArticleDOI
Essential oils in combination and their antimicrobial properties.
TL;DR: An overview on the antimicrobial efficacy of combinations of EOs and their isolated components is provided, taking advantage of their synergistic and additive effects.
Journal ArticleDOI
Natural products as antimicrobial agents
Rabin Gyawali,Salam A. Ibrahim +1 more
TL;DR: The antibacterial activity of natural components from different sources including plants, animals, bacteria, algae and mushrooms, and their potential use in food systems are reviewed.
Journal ArticleDOI
Invited review: Essential oils as modifiers of rumen microbial fermentation.
TL;DR: Because plant extracts may act at different levels in the carbohydrate and protein degradation pathways, their careful selection and combination may provide a useful tool to manipulate rumen microbial fermentation effectively.
References
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Journal ArticleDOI
Interactions of cyclic hydrocarbons with biological membranes.
TL;DR: The impairment of microbial activity by the cyclic hydrocarbons most likely results from hydrophobic interaction with the membrane, which affects the functioning of the membrane and membrane-embedded proteins.
Book
Identification of Essential Oils by Ion trap Mass Spectroscopy
TL;DR: The ion trap mass spectra of the most common terpenes (hydrocarbons found in oils, resins, and balsams) found in nature are presented in this article.
Journal ArticleDOI
Antibacterial properties of plant essential oils
S.G. Deans,G. Ritchie +1 more
TL;DR: The ten most inhibitory oils were thyme, cinnamon, bay, clove, almond (bitter), lovage, pimento, marjoram, angelica and nutmeg.
Journal ArticleDOI
Antibacterial activity of some essential oil components against five foodborne pathogens
TL;DR: These compounds could serve as potential antibacterial agents to inhibit pathogen growth in food by acting as minimum inhibitory and minimum bactericidal concentrations (MIC and MBC, respectively).
Journal ArticleDOI
Screening methods for natural products with antimicrobial activity: a review of the literature.
TL;DR: All the various techniques are reviewed here and, in order to unify the different criteria and parameters, standard methods to study the antimicrobial activity of medicinal plants are proposed.
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