Open AccessJournal Article
Theory of the process of amino-acid metabolism, catalysed by pyridoxal enzymes.
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This article is published in Biokhimiya.The article was published on 1953-01-01 and is currently open access. It has received 106 citations till now. The article focuses on the topics: Pyridoxal.read more
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Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure.
J. F. Kirsch,Gregor Eichele,Geoffrey C. Ford,M. G. Vincent,Johan N. Jansonius,Heinz Gehring,Philipp Christen +6 more
TL;DR: A mechanism of action is proposed that delineates the dynamic role of the protein moiety of this enzyme based on crystallographically determined spatial structures of the mitochondrial isoenzyme in its unliganded forms and in complexes with substrate analogues, as well as on model building studies.
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Dialkylglycine Decarboxylase Structure: Bifunctional Active Site and Alkali Metal Sites
TL;DR: Model building suggests that a single cleavage site catalyzes both decarboxylation and transamination by maximizing stereoelectronic advantages and providing electrostatic and general base catalysis.
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The relation of spectral changes and tritium exchange reactions to the mechanism of tryptophanase-catalyzed reactions.
Y. Morino,Esmond E. Snell +1 more
TL;DR: Results show that the β elimination reaction per se is the rate-limiting step in the holotryptophanase reactions, and support fully the mechanism shown in Equation 1.
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Tyrosine Phenol Lyase I. PURIFICATION, CRYSTALLIZATION, AND PROPERTIES
TL;DR: Crystalline l-tyrosine phenol lyase (deaminating) was prepared from the cell extract of Escherichia intermedia A-21 grown in a medium supplemented with l-TYrosine and catalyzed the stoichiometric conversion of l-Tyrosine into phenol, pyruvate, and ammonia, in the presence of added pyridoxal phosphate.
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High-Yield Biocatalytic Amination Reactions in Organic Synthesis
John M. Ward,Roland Wohlgemuth +1 more
TL;DR: The biocatalytic processes that have been developed show different strategies of overcoming the kinetic limitations of the transaminase reactions and show how some enzymes have been used in processes to make large quantities of chiral compounds with amino functionalities.