Journal ArticleDOI
Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow : The dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis
TLDR
Radioactive microspheres (12–16 μm) were used to measure cardiac output, its fractional distribution, and hence tissue blood flow in conscious, warm-acclimated or cold-acClimated white rats exposed to temperatures of 25, 21, 6, −6, and −19 °C, the objective being to assess the tissue distribution of cold-induced thermogenesis.Abstract:
Radioactive microspheres (12–16 μm) were used to measure cardiac output (CO), its fractional distribution, and hence tissue blood flow in conscious, warm-acclimated (WA) or cold-acclimated (CA) whi...read more
Citations
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Journal ArticleDOI
Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
TL;DR: The development of brown adipose tissue with its characteristic protein, uncoupling protein-1 (UCP1), was probably determinative for the evolutionary success of mammals, as its thermogenesis enhances neonatal survival and allows for active life even in cold surroundings.
Journal ArticleDOI
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
D. F. S. Rolfe,Guy C. Brown +1 more
TL;DR: The differences in standard metabolic rate between animals of different body mass and phylogeny appear to be due to proportionate changes in the whole of energy metabolism.
Journal ArticleDOI
Towards a molecular understanding of adaptive thermogenesis.
TL;DR: There have been significant advances in understanding the molecular regulation of energy expenditure in mitochondria and the mechanisms of transcriptional control of mitochondrial genes in relation to classical physiological views of adaptive thermogenesis.
Journal ArticleDOI
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Sven Enerbäck,Anders Jacobsson,Elizabeth M. Simpson,Carmen Guerra,Hitoshi Yamashita,Mary-Ellen Harper,Leslie P. Kozak +6 more
TL;DR: In this article, the role of UCP in the regulation of body mass was determined by targeted inactivation of the gene encoding it, and it was found that UCP-deficient mice consume less oxygen after treatment with a β3-adrenergic-receptor agonist and are sensitive to cold, indicating that their thermo-regulation is defective.
Journal ArticleDOI
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Bradford B. Lowell,Vedrana S-Susulic,Andreas Hamann,Joel A. Lawitts,Jean Himms-Hagen,Bert B. Boyer,Leslie P. Kozak,Jeffrey S. Flier +7 more
TL;DR: A critical role for brown adipose tissue in the nutritional homeostasis of mice is supported and obesity develops in the absence of hyperphagia, indicating that brown fat deficient mice have increased metabolic efficiency.
References
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Journal ArticleDOI
Use of the Pauling Oxygen Analyzer for Measurement of Oxygen Consumption of Animals in Open-Circuit Systems and in a Short-Lag, Closed-Circuit Apparatus
Florent Depocas,J. S. Hart +1 more
TL;DR: A basic formulation of methods of obtaining oxygen consumption data from measurements of oxygen partial pressure in open and closed-circuit systems is made.
Journal ArticleDOI
Use of radioactive microspheres to assess distribution of cardiac output in rabbits
JM Neutze,F Wyler,AM Rudolph +2 more