Journal ArticleDOI
Treatment of fibroadenomatosis in 14 cats with aglepristone – changes in blood parameters and follow-up
TLDR
Fourteen female cats with fibroadenomatosis were treated with aglepristone, and the effectiveness of the treatment and its effect on selected haematological and blood chemistry parameters were studied.Abstract:
Fourteen female cats with fibroadenomatosis were treated with aglepristone, and the effectiveness of the treatment and its effect on selected haematological and blood chemistry parameters were studied. The cats were monitored for 12 months after the end of the treatment. Complete remission of the clinical signs was achieved on average 3·9 weeks after the treatment began; the success of the treatment confirmed the clinical diagnosis of fibroadenomatosis. During the course of the treatment the cats’ haematological parameters returned to normal. In cats that had previously been treated with longacting medroxyprogesterone acetate, treatment with aglepristone for five weeks was recommended. Cases of fibroadenomatosis reappearing after a few months should be regarded as new disease rather than a relapse. Six cats were subsequently mated and four gave birth to one or more litters; all the pregnancies proceeded normally with no clinically evident fibroadenomatosis. The other eight cats underwent ovariohysterectomy soon after the aglepristone treatment was completed.read more
Citations
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Consensus for the Diagnosis, Prognosis and Treatment of Canine Mammary Tumors. Brazilian Journal of Veterinary Pathology
Geovanni Dantas Cassali,Gleidice Eunice Lavalle,Andrigo Barboza De Nardi,Enio Ferreira,Angélica Cavalheiro Bertagnolli,Alessandra Estrela da Silva Lima,Antonio C. Alessi,Carlos R. Daleck,Breno S. Salgado,Cristina G. Fernandes,Renata Afonso Sobral,Renée L. Amorim,Conrado de Oliveira Gamba,Karine Araújo Damasceno,Patricia de Alencar Auler,Geórgia Modé Magalhães,Juliana O. Silva,Josiane B. Raposo,Ana Ferreira,Luciana Oliveira de Oliveira,Christina Malm,Debora Aparecida Pires de Campos Zuccari,Neide M. Tanaka,Lorena R. Ribeiro,Liliane Cunha Campos,Cristina Maria de Souza,Juliana da Silva Leite,Luciana M. C. Soares,Mariana F. Cavalcanti,Zilmara G. C. Fonteles,Isabel D. Schuch,Juliana Paniago,Taismara S. Oliveira,Erika M. Terra,Thais L. L. Castanheira,Anelize O. C. Felix,Gabriel D. Carvalho,Thomas N. Guim,Tainã Normanton Guim,Eduardo Garrido,Simone C. Fernandes,Frederico C. L. Maia,Maria Lúcia Zaidan Dagli,Noeme S. Rocha,Heidge Fukumasu,Fabrizio Grandi,João P. Machado,Silvana M. M. S. Silva,Juliana Evangelista Bezerril,Michele Salmon Frehse,Elan Cardozo Paes de Almeida,Cecília Bonolo de Campos +51 more
TL;DR: The main aspects of the diagnosis, prognosis and treatment of feline mammary neoplasia were discussed, aiming to standardize the criteria and to serve as a guide for pathologists and veterinary clinicians.
Steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues
TL;DR: The percentage of PR-positive feline carcinomas suggests a possible role of progesterone in promoting early tumour cell growth in queens and the low percentage of ER-positive invasive carcinomas further demonstrated the aggressive phenotype and behaviour of feline mammary tumours.
Journal ArticleDOI
Prognostic evaluation of feline mammary carcinomas: a review of the literature.
Valentina Zappulli,Roberta Rasotto,D. Caliari,M. Mainenti,Laura Peña,Michael H. Goldschmidt,Matti Kiupel +6 more
TL;DR: Examination of feline mammary tumor publications and postulated prognostic parameters suggests that marker expression may provide relevant information applicable for therapeutic predictions; however, consensus efforts and protocol standardization are needed.
Journal ArticleDOI
Aglepristone: A review on its clinical use in animals
Anne Gogny,Francis Fieni +1 more
TL;DR: Treatment of feline fibroadenomatosis using aglepristone has given promising results, but repeat treatment may be necessary in cats previously treated with long-acting progestagens.
Book ChapterDOI
Feline Mammary Fibroepithelial Hyperplasia: A Clinical Approach
TL;DR: Prevalence of mammary tumours in cats is highly variable with the geographic region, as it tends to be lower in areas where most cats are neutered at a young age, and little attention has been paid to benign mammary growths and mastectomy is still often performed.
References
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Journal ArticleDOI
Comparison of steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues
TL;DR: In this paper, the results showed that oestrogen-alpha (ER) and progesterone receptor (PR) expression was significantly higher in healthy tissues, hyperplastic/dysplastic lesions, and benign tumours than in carcinomas.
Steroid receptor expression in normal, dysplastic, and neoplastic canine and feline mammary tissues
TL;DR: The percentage of PR-positive feline carcinomas suggests a possible role of progesterone in promoting early tumour cell growth in queens and the low percentage of ER-positive invasive carcinomas further demonstrated the aggressive phenotype and behaviour of feline mammary tumours.
Journal ArticleDOI
New insights in the molecular mechanism of progestin-induced proliferation of mammary epithelium: Induction of the local biosynthesis of growth hormone (GH) in the mammary gland of dogs, cats and humans
TL;DR: It is concluded that the gene encoding GH is expressed in the mammary gland of a variety of species, including man, and appears to represent a contribution to the molecular explanation of the action of progestins on proliferation of mammary epithelium.
Journal Article
Ovulation without cervical stimulation in domestic cats.
TL;DR: The data suggest that, at least as far as cats housed in proximity to one another are concerned, intact female cats do not always require cervical stimulation to induce ovulation.
Journal Article
Incidence of spontaneous ovulation in young, group-housed cats based on serum and faecal concentrations of progesterone.
TL;DR: In a group-housed colony of 15 1-year-old domestic queens, 23 noncopulatory, spontaneous ovulations were observed in 87% of the queens over 4.5 months based upon the detection of increased concentrations of progesterone in faeces, serum, or both.