Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt1
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This article is published in Acta Physiologica.The article was published on 1904-07-01 and is currently open access. It has received 531 citations till now.read more
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Journal ArticleDOI
Copper Active Sites in Biology
Edward I. Solomon,David E. Heppner,Esther M. Johnston,Jake W. Ginsbach,Jordi Cirera,Munzarin F. Qayyum,Matthew T. Kieber-Emmons,Christian H. Kjaergaard,Ryan G. Hadt,Li Tian +9 more
TL;DR: This review presents in depth discussions of all these classes of Cu enzymes and the correlations within and among these classes, as well as the present understanding of the enzymology, kinetics, geometric structures, electronic structures and the reaction mechanisms these have elucidated.
Journal ArticleDOI
Allosteric modulation of G protein-coupled receptors.
TL;DR: Because of their ability to modulate receptor conformations in the presence of orthosteric ligand, allosteric modulators can "fine-tune" classical pharmacological responses, which is advantageous in terms of a potential for engendering greater GPCR subtype-selectivity, but represents a significant challenge for detecting and validating allosterIC behaviors.
Journal ArticleDOI
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control.
Zhi Huang,Sruti Shiva,Daniel B. Kim-Shapiro,Rakesh P. Patel,Lorna A. Ringwood,Cynthia E. Irby,Kris T. Huang,Chien Ho,Neil Hogg,Alan N. Schechter,Mark T. Gladwin +10 more
TL;DR: In this article, the authors show biochemical evidence that hemoglobin exhibits enzymatic behavior as a nitrite reductase, with maximal NO generation rates occurring near the oxy-to-deoxy (Rto-T) allosteric structural transition of the protein.
Book ChapterDOI
Hemoglobin and myoglobin.
TL;DR: This chapter describes hemoglobin and myoglobin, and briefly describes some properties and reactions of their prosthetic group, mainly because the characteristic physiological functions of these proteins arise from the intrinsic reactivity of the heme.
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On the Nature of Allosteric Transitions: A Plausible Model
The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin.
Reinhold Benesch,Ruth E. Benesch +1 more