Understanding the Epidemiology and Progression of Systemic Lupus Erythematosus
Guillermo J. Pons-Estel,Graciela S. Alarcón,Lacie Scofield,Lacie Scofield,Leslie Reinlib,Glinda S. Cooper,Glinda S. Cooper +6 more
TLDR
The understanding of ways to improve outcomes in SLE patients could benefit from patient-oriented research focusing on many dimensions of disease burden, and promising research initiatives include the inclusion of community-based patients in longitudinal studies, and use of self-assessment tools for rating disease damage and activity.About:
This article is published in Seminars in Arthritis and Rheumatism.The article was published on 2010-02-01 and is currently open access. It has received 761 citations till now. The article focuses on the topics: Disease burden & Lupus erythematosus.read more
Citations
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Systemic lupus erythematosus.
Arvind Kaul,Caroline Gordon,Mary K. Crow,Zahi Touma,Murray B. Urowitz,Ronald F van Vollenhoven,Guillermo Ruiz-Irastorza,Graham R. V. Hughes +7 more
TL;DR: The 10-year mortality has improved and toxic adverse effects of older medications such as cyclophosphamide and glucocorticoids have been partially offset by newer drugs such as mycophenolate mofetil and glucose-sparing regimes.
Journal ArticleDOI
Human autoimmune diseases: a comprehensive update.
TL;DR: The identification of cytokines and chemokines, and their cognate receptors, has led to novel therapies that block pathological inflammatory responses within the target organ and have greatly improved the therapeutic effect in patients with autoimmune disease, particularly rheumatoid arthritis.
Journal ArticleDOI
Update on Lupus Nephritis
TL;DR: This review highlights recent updates in the understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupu.
Journal ArticleDOI
Superwoman Schema: African American Women’s Views on Stress, Strength, and Health
TL;DR: A preliminary conceptual framework for Superwoman Schema (SWS) is developed by exploring women’s descriptions of the Superwoman role; perceptions of contextual factors, benefits, and liabilities; and beliefs regarding how it influences health.
Journal ArticleDOI
Systemic lupus erythematosus: Diagnosis and clinical management.
Andrea Fava,Michelle Petri +1 more
TL;DR: The diagnostic approach as well as the etiopathogenetic rationale and clinical evidence for the management of SLE are reviewed, which includes lifestyle changes such as avoidance of ultraviolet light; prevention of comorbidities including coronary artery disease, osteoporosis, infections, and drug toxicities; use of immunomodulators and targeted therapy.
References
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
TL;DR: In 1992, Piette and colleagues suggested that the ACR revised criteria be reevaluated in light of the above discoveries, and the presence and clinical associations or antiphospholipid antibodies in patients with SLE was suggested.
Book
Systemic Lupus Erythematosus
TL;DR: Contributions are gathered from physicians and researchers from North America, South America, Europe, and Asia that highlight several important and/or novel aspects of the molecular pathogenesis, clinical organ involvement, and experimental therapies in this prototypical systemic autoimmune disease.
Journal ArticleDOI
The bimodal mortality pattern of systemic lupus erythematosus
Murray B. Urowitz,Arthur Bookman,Barry E. Koehler,Duncan A. Gordon,Hugh A. Smythe,Metro A. Ogryzlo +5 more
TL;DR: An examination of the deaths in a long-term systematic analysis of 81 patients followed for five years at the University of Toronto Rheumatic Disease Unit found death is associated with inactive lupus, long duration of steroid therapy and a striking incidence of myocardial infarction due to atherosclerotic heart disease.
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